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Cat.No. : CSC-RI0023 Host Cell: CHO-K1
| Cat. No. | CSC-RI0023 |
| Description | This cell line is engineered to overexpress human KCNQ1/MINK1. |
| Background | KCNQ1 and minK form the slow delayed rectifier potassium current, IKs in the heart. This multimeric ion channel contributes to cardiac action potential repolarization and determines the heartbeat rate. Mutations in either KCNQ1 or minK that reduce IKs have been shown to cause long-QT syndrome (LQTS), a disorder of ventricular repolarization that can result in cardiac arrhythmia and sudden death. A well-recognized potential treatment for LQTS caused by reduction of IKs is to enhance functional activation of cardiac KCNQ1/minK channels. |
| Gene | KCNQ1/MINK1 |
| Gene Species | Homo sapiens (Human) |
| Alias | MINK1, hMINK, hMINKbeta, MGC21111 |
| Host Cell | CHO-K1 |
| Host Cell Species | Cricetulus griseus (Chinese hamster) |
| Morphology | Epithelial-like |
| Stability | Validated for at least 10 passages |
| Application | 1. Gene expression studies 2. Signaling pathway research 3. Drug screening and toxicology 4. Channelopathies research |
| Quality Control | Negative for bacteria, yeast, fungi and mycoplasma. |
| Shipping | Dry ice |
| Storage | Liquid nitrogen |
| Revival | Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media. |
| Growth Properties | Adherent |
| Mycoplasma | Negative |
| Format | One frozen vial containing millions of cells |
| Storage | Liquid nitrogen |
| Safety Considerations |
The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach. |
| Ship | Dry ice |
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