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Human KCNN4 Stable Cell Line-CHO

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Cat.No.
CSC-RI0112
Background
The human KCNN4 gene encodes the pore-forming subunit of KCa3.1, the calcium-activated IK potassium channel. KCa3.1 channels expressed in lymphocytes, fibroblasts, proliferating vascular smooth muscle cells, vascular endothelium and, intestinal and airway epithelia are therapeutic targets in inflammatory diseases in these tissues. KCa3.1 channels expressed in erthrocytes have been investigated as targets for treatment of sickle cell anemia.
Growth Properties
Adherent
Morphology
Epithelial-like
Host Cell
CHO-K1
Ship
Dry ice
Gene Information
Gene Name
KCNN4 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 [ Homo sapiens ]
Official Symbol
KCNN4
Synonyms
KCNN4; potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4; intermediate conductance calcium-activated potassium channel protein 4; hIKCa1; hKCa4; hSK4; KCa3.1; SKCa4; SKCa 4; putative Gardos channel; putative erythrocyte intermediate conductance calcium-activated potassium Gardos channel; IK1; SK4; KCA4; IKCA1;
Gene ID
3783
MIM
602754
UniProt ID
O15554
Chromosome Location
19q13.2
Pathway
Ca2+ activated K+ channels, organism-specific biosystem; Neuronal System, organism-specific biosystem; Potassium Channels, organism-specific biosystem; Protein digestion and absorption, organism-specific biosystem; Protein digestion and absorption, conserved biosystem; Salivary secretion, organism-specific biosystem; Salivary secretion, conserved biosystem;
Function
calcium-activated potassium channel activity; calmodulin binding; ion channel activity; protein phosphatase binding; small conductance calcium-activated potassium channel activity;

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