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Cat.No. : CSC-RI0112 Host Cell: CHO-K1
| Cat. No. | CSC-RI0112 |
| Description | This cell line is engineered to overexpress human KCNN4. |
| Background | The human KCNN4 gene encodes the pore-forming subunit of KCa3.1, the calcium-activated IK potassium channel. KCa3.1 channels expressed in lymphocytes, fibroblasts, proliferating vascular smooth muscle cells, vascular endothelium and, intestinal and airway epithelia are therapeutic targets in inflammatory diseases in these tissues. KCa3.1 channels expressed in erthrocytes have been investigated as targets for treatment of sickle cell anemia. |
| Gene | KCNN4 |
| Gene Species | Homo sapiens (Human) |
| Alias | KCNN4, hIKCa1, hKCa4, hSK4, KCa3.1, SKCa4, SKCa 4, IK1, SK4, KCA4, IKCA1 |
| Host Cell | CHO-K1 |
| Host Cell Species | Cricetulus griseus (Chinese hamster) |
| Morphology | Epithelial-like |
| Stability | Validated for at least 10 passages |
| Application | 1. Gene expression studies 2. Signaling pathway research 3. Drug screening and toxicology 4. Channelopathies research |
| Quality Control | Negative for bacteria, yeast, fungi and mycoplasma. |
| Shipping | Dry ice |
| Storage | Liquid nitrogen |
| Revival | Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media. |
| Growth Properties | Adherent |
| Mycoplasma | Negative |
| Format | One frozen vial containing millions of cells |
| Storage | Liquid nitrogen |
| Safety Considerations |
The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach. |
| Ship | Dry ice |
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