Human KCNN3 Stable Cell Line-CHO-K1

Name: Human KCNN3 Stable Cell Line-CHO-K1
SKU: CSC-RI0110
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-RI0110

Host Cell : CHO-K1 Size : >1x10⁶ frozen cells/vial

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Cell Line Information

Cell Culture Information

Safety and Packaging

Gene Information

Cat. No.	CSC-RI0110
Description	This cell line is engineered to overexpress human KCNN3.
Background	The human KCNN3 gene encodes the pore-forming subunit of KCa2.3, the calcium-activated, voltage-gated SK3 potassium channel. KCa2 channels are responsible for afterhyperpolarization that regulates neuronal repetitive excitation. KCa2.3 channels expressed in CNS neurons are therapeutic targets in neurologic disorders (e.g., cognitive impairment and seizure).
Target Gene	KCNN3
Gene Species	Homo sapiens (Human)
Abbr	CHO-HuKCNN3
Alias	KCNN3, hSK3, KCa2.3, SKCA3, SKCa 3, SK3
Host Cell	CHO-K1
Host Cell Species	Cricetulus griseus (Chinese hamster)
Applications	1. Gene expression studies 2. Signaling pathway research 3. Drug screening and toxicology 4. Channelopathies research
Size	>1x10⁶ frozen cells/vial
Stability	Validated for at least 10 passages
Quality Control	Negative for bacteria, yeast, fungi and mycoplasma.
Storage	Liquid nitrogen
Shipping	Dry ice

Revival	Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media.
Growth Properties	Adherent
Morphology	Epithelial-like

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

Gene Name	KCNN3 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3 [ Homo sapiens ]
Gene Symbol	KCNN3
Synonyms	KCNN3; potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3; small conductance calcium-activated potassium channel protein 3; hSK3; KCa2.3; SKCA3; SKCa 3; SK3;
Gene ID	3782
Uni Prot ID	Q9UGI6
m RNA Refseq	BC042147
Chromosome Location	1q21.3
Function	calmodulin binding; ion channel activity; potassium channel activity; small conductance calcium-activated potassium channel activity;
Pathway	Ca2+ activated K+ channels, organism-specific biosystem; Neuronal System, organism-specific biosystem; Potassium Channels, organism-specific biosystem;
MIM	602983

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