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Human HTR2B Stable Cell Line-CHO

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Cat.No.
CSC-RG0779
Background
Serotonin (5-hydroxytryptamine, 5-HT) exerts its many physiological effects through 13 distinct receptor subtypes in humans. These subtypes fall into seven structurally-defined classes (5-HT1 to 5-HT7). 5-HT2B receptors are expressed in the liver, kidney, lung, heart, pancreas, spleen, brain, spinal cord, gastrointestinal tract, placenta, and coronary and pulmonary arteries. It has also been reported in embryonic mouse heart. This receptor has been used as a target for developing drugs to treat migraine, anxiety, and irritable bowel syndrome.
Growth Properties
Adherent
Morphology
Epithelial-like
Host Cell
CHO-K1
Stability
6 passages (3 weeks of continuous culture)
Ship
Dry ice
Gene Information
Official Symbol
HTR2B
Synonyms
HTR2B; 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled; 5 hydroxytryptamine (serotonin) receptor 2B; 5-hydroxytryptamine receptor 2B; 5 HT(2B); 5 HT2B; 5-HT-2B; 5-HT 2B receptor; serotonin receptor 2B; 5-hydroxytryptamine 2B receptor; 5-hydroxytryptamine receptor 2B variant b; 5-HT2B; 5-HT(2B);
Gene ID
MIM
UniProt ID
P41595
Chromosome Location
2q36.3-q37.1
Pathway
Amine ligand-binding receptors, organism-specific biosystem; Calcium signaling pathway, organism-specific biosystem; Calcium signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (q) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem;
Function
G-protein alpha-subunit binding; G-protein coupled receptor activity; Ras GTPase activator activity; calcium channel activity; drug binding; phosphatidylinositol phospholipase C activity; phosphatidylinositol phospholipase C activity; receptor activity; serotonin binding; serotonin receptor activity; signal transducer activity;

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