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Human HRH1 Stable Cell Line-HEK293

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Cat.No.
CSC-RG1634
Background
Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. The protein encoded by this gene is an integral membrane protein and belongs to the G protein-coupled receptor superfamily. It mediates the contraction of smooth muscles, the increase in capillary permeability due to contraction of terminal venules, the release of catecholamine from adrenal medulla, and neurotransmission in the central nervous system. It has been associated with multiple processes, including memory and learning, circadian rhythm, and thermoregulation. It is also known to contribute to the pathophysiology of allergic diseases such as atopic dermatitis, asthma, anaphylaxis and allergic rhinitis. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Host Cell
HEK293
Ship
Dry Ice
Antigen Gene Information
Official Symbol
HRH1
Synonyms
HRH1; histamine receptor H1; histamine H1 receptor; H1R; HH1R; histamine H receptor; histamine receptor, subclass H1; H1-R; hisH1;
GeneID
MIM
UniProt ID
P35367
Chromosome Location
3p25
Pathway
Amine ligand-binding receptors, organism-specific biosystem; Calcium signaling pathway, organism-specific biosystem; Calcium signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (q) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem;
Function
G-protein coupled receptor activity; histamine binding; histamine receptor activity; receptor activity; signal transducer activity;

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