Rat Hrh1 ORF Clone(NM_017018.1)

Name: Rat Hrh1 ORF Clone(NM_017018.1)
SKU: CDCR378131
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDCR378131

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Product Information

Gene Information

Cat. No.	CDCR378131
Product Type	ORF Clone
Gene Abbr	Hrh1
Species	Rat
Tag	C-terminal Myc-DDK
ORF Size	1461 bp
Vector	pCMV6-Entry

Target Gene

HRH1

Background

Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. The protein encoded by this gene is an integral membrane protein and belongs to the G protein-coupled receptor superfamily. It mediates the contraction of smooth muscles, the increase in capillary permeability due to contraction of terminal venules, the release of catecholamine from adrenal medulla, and neurotransmission in the central nervous system. It has been associated with multiple processes, including memory and learning, circadian rhythm, and thermoregulation. It is also known to contribute to the pathophysiology of allergic diseases such as atopic dermatitis, asthma, anaphylaxis and allergic rhinitis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2015]

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