Human HCRTR1 Stable Cell Line-CHO-K1

Name: Human HCRTR1 Stable Cell Line-CHO-K1
SKU: CSC-RG0908
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-RG0908

Host Cell : CHO-K1 Size : >1x10⁶ frozen cells/vial

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Cell Line Information

Cell Culture Information

Safety and Packaging

Gene Information

Cat. No.	CSC-RG0908
Background	Orexin-A and orexin-B are peptides expressed in brain that have been implicated in controlling feeding behavior, energy homeostasis and sleep-wake cycle. These peptides exert their effects through two GPCRs, known as the orexin-1 and orexin-2 receptors, both of which are Gq/11-coupled.
Target Gene	HCRTR1
Gene Species	Homo sapiens (Human)
Abbr	CHO-HuHCRTR1
Alias	HCRTR1, OX1R, ox1-R, ox-1-R
Host Cell	CHO-K1
Host Cell Species	Cricetulus griseus (Chinese hamster)
Applications	1. Gene expression studies 2. Signaling pathway research 3. Drug screening and toxicology 4. Research on the mechanisms of GPCR-related diseases
Size	>1x10⁶ frozen cells/vial
Stability	Validated for at least 10 passages
Quality Control	Negative for bacteria, yeast, fungi and mycoplasma.
Storage	Liquid nitrogen
Shipping	Dry ice

Revival	Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media.
Growth Properties	Adherent
Morphology	Epithelial-like

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

Gene Name	HCRTR1 hypocretin (orexin) receptor 1 [ Homo sapiens ]
Gene Symbol	HCRTR1
Synonyms	OX1R
Gene ID	3061
Uni Prot ID	O43613
m RNA Refseq	NM_001525.2
Protein Refseq	NP_001516.2
Chromosome Location	1p33
Function	G-protein coupled receptor activity; orexin receptor activity;
Pathway	Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (q) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; GPCRs, Class A Rhodopsin-like, organism-specific biosystem; Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystem; Neuroactive ligand-receptor interaction, organism-specific biosystem;
MIM	602392

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