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Human GPR119 Stable Cell Line-CHO

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Cat.No.
CSC-RG0855
Background
GPR119 is expressed in insulin-producing beta cells where it modulates insulin release, thus making it a very attractive therapeutic target for metabolic disorders. GPR119 is activated by oleoylethanolamide (OEA) and by a novel selective small-molecule (PSN632408) which, when administered to high-fat-fed rats, suppresses food intake and reduces body weight gain. Another small molecule full-agonist (AR231453) enhances glucose-dependent insulin release, and improves oral glucose tolerance in wild-type mice, but not in GPR119 knock-out mice.
Growth Properties
Adherent
Morphology
Epithelial-like
Host Cell
CHO-K1
Stability
12 passages
Ship
Dry ice
Gene Information
Official Symbol
GPR119
Synonyms
GPR119; G protein-coupled receptor 119; glucose-dependent insulinotropic receptor; GPCR2; hGPCR2; G-protein coupled receptor 2; G-protein coupled receptor 119; MGC119957;
Gene ID
MIM
UniProt ID
Q8TDV5
Chromosome Location
Xq26.1
Pathway
Incretin Synthesis, Secretion, and Inactivation, organism-specific biosystem; Integration of energy metabolism, organism-specific biosystem; Metabolism, organism-specific biosystem; Regulation of Insulin Secretion, organism-specific biosystem; Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1), organism-specific biosystem; Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP), organism-specific biosystem;
Function
G-protein coupled receptor activity; lipid binding; receptor activity; signal transducer activity;

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