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Human GCGR Validated Stable Cell Line-1321N1

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Cat.No.
CSC-RG1164
Background
Glucagon is a 29-amino acid peptide that stimulates glycogenolysis and gluconeogenesis in the liver to increase blood glucose. The receptor for glucagon is a class 2 (or class B) GPCR that signals through Gs to stimulate cAMP production. Mice lacking the glucagon receptor have mild hypoglycemia after fasting, and exhibit hyperplasia of pancreatic alpha-cells. Because of its role in promoting hyperglycemia, the glucagon receptor presents a potential target for treatment of diabetes.
Growth Properties
Adherent
Morphology
Glial
Host Cell
1321N1
Ship
Dry ice
Gene Information
Official Symbol
GCGR
Synonyms
GCGR; glucagon receptor; GGR; GL-R; FLJ97182; MGC138246;
Gene ID
MIM
UniProt ID
P47871
Chromosome Location
17q25
Pathway
Class B/2 (Secretin family receptors), organism-specific biosystem; G alpha (q) signalling events, organism-specific biosystem; G alpha (s) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; GPCRs, Class B Secretin-like, organism-specific biosystem; Glucagon signaling in metabolic regulation, organism-specific biosystem;
Function
glucagon receptor activity; guanyl-nucleotide exchange factor activity; peptide hormone binding; receptor activity; signal transducer activity;

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