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Human DRD5-tGFP Stable Cell Line-SHSY5Y

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Cat.No.
CSC-RG0038
Background
The gene encodes the D5 subtype of the Dopamine receptor. This subtype is a G-protein coupled receptor which stimulates adenylyl cyclase. Dopamine is one of the most important neurotransmitters and the expression of its receptors is well characterized in brain.
Dopamine receptors are involved in many neurological processes so their abnormal signalling is implicated in several neuropsychiatric disorders. Defects in DRD5 are a cause of benign essential blepharospasm (BEB), a primary focal dystonia affecting the orbicularis oculi muscles.
Growth Properties
Mixed, adherent and suspension
Morphology
Epithelial
Host Cell
SHSY5Y
Ship
Dry ice
Gene Information
Official Symbol
DRD5
Synonyms
DRD5; dopamine receptor D5; DRD1L2; D(1B) dopamine receptor; DRD1B; dopamine D5 receptor; dopamine receptor D1B; d dopamine receptor; D1beta dopamine receptor; DBDR; MGC10601;
Gene ID
UniProt ID
P21918
Chromosome Location
4p16.1
Pathway
Amine ligand-binding receptors, organism-specific biosystem; Calcium signaling pathway, organism-specific biosystem; Calcium signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Dopamine receptors, organism-specific biosystem; Dopaminergic synapse, organism-specific biosystem; Dopaminergic synapse, conserved biosystem;
Function
G-protein alpha-subunit binding; G-protein coupled receptor activity; dopamine binding; dopamine receptor activity; dopamine receptor activity, coupled via Gs; drug binding; receptor activity; signal transducer activity;

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