Human CNR1 Stable Cell Line-CHO-K1

Name: Human CNR1 Stable Cell Line-CHO-K1
SKU: CSC-RG0809
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-RG0809

Host Cell : CHO-K1 Size : >1x10⁶ frozen cells/vial

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Cell Line Information

Cell Culture Information

Safety and Packaging

Gene Information

Cat. No.	CSC-RG0809
Background	The CB1 cannabinoid receptor is expressed primarily in brain and is a target for cannabinoids (Matsuda et al., 1990, Gerard et al., 1991), the psychoactive ingredients of marijuana. Other members of the cannabinoid family of receptors include the CB2 cannabinoid receptor which is expressed primarily in the periphery, and GPR55 (Ryberg, 2007 ). When activated, the CB1 receptor inhibits adenylate cyclase through Gi. The CB1 receptor play a significant role in modulation of food intake (Cota, 2007)
Target Gene	CNR1
Gene Species	Homo sapiens (Human)
Abbr	CHO-HuCNR1
Alias	CNR1, CNR, CANN6, CB R, CB1, CB1A, CB1K5, CB-R, CB1R
Host Cell	CHO-K1
Host Cell Species	Cricetulus griseus (Chinese hamster)
Applications	1. Gene expression studies 2. Signaling pathway research 3. Drug screening and toxicology 4. Research on the mechanisms of GPCR-related diseases
Size	>1x10⁶ frozen cells/vial
Stability	Validated for at least 10 passages
Quality Control	Negative for bacteria, yeast, fungi and mycoplasma.
Storage	Liquid nitrogen
Shipping	Dry ice

Revival	Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media.
Growth Properties	Adherent
Morphology	Epithelial-like

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

Gene Name	CNR1 cannabinoid receptor 1 (brain) [ Homo sapiens ]
Gene Symbol	CNR1
Synonyms	CNR1; cannabinoid receptor 1 (brain); CNR; cannabinoid receptor 1; CANN6; CB R; CB1; CB1A; CB1K5; central cannabinoid receptor; CB-R; CB1R;
Gene ID	1268
Uni Prot ID	P21554
Chromosome Location	6q14-q15
Function	cannabinoid receptor activity; drug binding; receptor activity; signal transducer activity;
Pathway	Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (i) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; GPCRs, Class A Rhodopsin-like, organism-specific biosystem; N-cadherin signaling events, organism-specific biosystem; Neuroactive ligand-receptor interaction, organism-specific biosystem;
MIM	114610

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