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Human AVPR1A Stable Cell Line-HEK293

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Cat.No.
CSC-RG0018
Background
The activity of Arginine Vasopressin receptor 1A (AVPR1A) is mediated by G proteins which stimulate a phosphatidylinositol-calcium second messenger system. Arginine Vasopressin 1A receptor belongs to the same subfamily of G-protein coupled receptors of AVPR1B, V2R and Oxytocin receptors. The receptor mediates cell contraction and proliferation, platelet aggregation, release of coagulation factor and glycogenolysis. V1A is coupled to Gq/11 proteins and is found at high density on smooth muscle cells. It is involved in regulation of blood pressure through arterial vasoconstriction and has been found to stimulate VEGF secretion. AVPR1A is widely expressed in the brain and it has been implicated in social behaviours, including affiliation and attachment and related to diseases as autism.
Growth Properties
Adherent
Morphology
Epithelial
Host Cell
HEK293
Ship
Dry ice
Gene Information
Official Symbol
AVPR1A
Synonyms
AVPR1A; arginine vasopressin receptor 1A; AVPR1; vasopressin V1a receptor; V1aR; AVPR V1a; V1a vasopressin receptor; antidiuretic hormone receptor 1A; SCCL vasopressin subtype 1a receptor; V1-vascular vasopressin receptor AVPR1A; vascular/hepatic-type arginine vasopressin receptor;
Gene ID
MIM
UniProt ID
P37288
Chromosome Location
12q14-q15
Pathway
Calcium signaling pathway, organism-specific biosystem; Calcium signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (q) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; GPCRs, Class A Rhodopsin-like, organism-specific biosystem;
Function
G-protein coupled receptor activity; V1A vasopressin receptor binding; peptide hormone binding; protein binding; protein kinase C binding; receptor activity; signal transducer activity; vasopressin receptor activity;

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