Human AVPR1A Stable Cell Line-CHO-K1

Name: Human AVPR1A Stable Cell Line-CHO-K1
SKU: CSC-RG0936
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-RG0936

Host Cell : CHO-K1 Size : >1x10⁶ frozen cells/vial

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Cell Line Information

Cell Culture Information

Safety and Packaging

Gene Information

Cat. No.	CSC-RG0936
Background	The pituitary hormone vasopressin (AVP) is a cyclic nonapeptide that acts by binding to a family of vasopressin receptors that includes the V1a, V1b, and V2 receptors. V1a receptors have been shown to be expressed in vascular smooth muscle, hepatocytes, various blood cells, brain, and retina. These receptors mediate cell proliferation, platelet aggregation, coagulation factor release and glycogenolysis. This cell line is useful for both radioligand binding and for functional assays.
Target Gene	AVPR1A
Gene Species	Homo sapiens (Human)
Abbr	CHO-HuAVPR1A
Alias	AVPR1A, AVPR1, V1aR
Host Cell	CHO-K1
Host Cell Species	Cricetulus griseus (Chinese hamster)
Applications	1. Gene expression studies 2. Signaling pathway research 3. Drug screening and toxicology 4. Research on the mechanisms of GPCR-related diseases
Size	>1x10⁶ frozen cells/vial
Stability	Validated for at least 10 passages
Quality Control	Negative for bacteria, yeast, fungi and mycoplasma.
Storage	Liquid nitrogen
Shipping	Dry ice

Revival	Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media.
Growth Properties	Adherent
Morphology	Epithelial-like

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

Gene Name	AVPR1A arginine vasopressin receptor 1A [ Homo sapiens ]
Gene Symbol	AVPR1A
Synonyms	V1aR; AVPR1; AVPR V1a
GeneID	552
Uni ProtID	P37288
mRNA Refseq	NM_000706.4
Protein Refseq	NP_000697.1
Chromosome Location	12q14-q15
Function	V1A vasopressin receptor binding; peptide hormone binding; protein binding; protein kinase C binding; vasopressin receptor activity;
Pathway	Calcium signaling pathway, organism-specific biosystem; Calcium signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (q) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; GPCRs, Class A Rhodopsin-like, organism-specific biosystem;
MIM	600821

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