Human ADRA1A Stable Cell Line-U2OS

Name: Human ADRA1A Stable Cell Line-U2OS
SKU: CSC-RG0012
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-RG0012

Host Cell : U2OS Size : >1x10⁶ frozen cells/vial

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Cell Line Information

Cell Culture Information

Safety and Packaging

Gene Information

Cat. No.	CSC-RG0012
Background	Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins. The alpha-adrenergic receptor (AR) subtypes (alpha(1a), alpha(1b), and alpha(1d)) mediate some physiological effects of epinephrine and norepinephrine. The alpha1-AR subtypes are expressed in several organs like brain or heart in which they modulate a diversity of functional effects such as modulation of neurotransmission, vasoconstriction, etc.
Target Gene	ADRA1A
Gene Species	Homo sapiens (Human)
Abbr	U2OS-HuADRA1A
Alias	ADRA1A, ADRA1C, ADRA1L1, ALPHA1AAR
Host Cell	U2OS
Host Cell Species	Homo sapiens (Human)
Applications	1. Gene expression studies 2. Signaling pathway research 3. Drug screening and toxicology 4. Research on the mechanisms of GPCR-related diseases
Size	>1x10⁶ frozen cells/vial
Stability	Validated for at least 10 passages
Quality Control	Negative for bacteria, yeast, fungi and mycoplasma.
Storage	Liquid nitrogen
Shipping	Dry ice

Revival	Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media.
Growth Properties	Adherent

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

Gene Name	ADRA1A adrenoceptor alpha 1A [ Homo sapiens ]
Gene Symbol	ADRA1A
Synonyms	ADRA1C; ADRA1L1; ALPHA1AAR
Gene Description	adrenergic, alpha-1A-, receptor
GeneID	148
Uni ProtID	P35348
mRNA Refseq	NM_000680.2
Protein Refseq	NP_000671.2
Chromosome Location	8p21.2
Function	alpha1-adrenergic receptor activity; alpha1-adrenergic receptor activity; alpha1-adrenergic receptor activity; protein heterodimerization activity;
Pathway	AMPK signaling, organism-specific biosystem; Adrenoceptors, organism-specific biosystem; Amine ligand-binding receptors, organism-specific biosystem; Calcium Regulation in the Cardiac Cell, organism-specific biosystem; Calcium signaling pathway, organism-specific biosystem; Calcium signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem;
MIM	104221

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Customer Reviews

Customer Q&As

What is the role of the Human ADRA1A Stable Cell Line-U2OS in studying adrenergic receptor signaling?

A: The Human ADRA1A Stable Cell Line-U2OS, established by stably expressing the human α1A adrenergic receptor (ADRA1A) in U2OS cells, is crucial for studying how adrenergic receptors regulate intracellular signaling and physiological responses. It aids scientists in understanding the role of ADRA1A in the cardiovascular system, nervous system, and stress responses.

How is the Human ADRA1A Stable Cell Line-U2OS applied in drug screening and development?

A: Drug screening on the Human ADRA1A Stable Cell Line-U2OS allows researchers to evaluate the affinity and effects of potential drugs on ADRA1A. This cell line provides a platform for testing the impact of drugs on ADRA1A signaling, which is significant for developing drugs to treat cardiovascular diseases.

What is the role of the Human ADRA1A Stable Cell Line-U2OS in studying the impact of ADRA1A gene mutations on cellular function?

A: The Human ADRA1A Stable Cell Line-U2OS allows scientists to investigate how ADRA1A gene mutations affect cellular function. By comparing the expression and function of wild-type and mutant ADRA1A, researchers can better understand how these mutations lead to changes in cellular signal transduction, which is significant for the study of genetic cardiovascular diseases.

How is the Human ADRA1A Stable Cell Line-U2OS applied in studying the role of ADRA1A in stress responses?

A: The Human ADRA1A Stable Cell Line-U2OS can be used to study the role of ADRA1A in stress responses, particularly in dealing with environmental stressors and physiological challenges. This cell line helps scientists understand the molecular mechanisms of ADRA1A in regulating stress responses, which has potential value for developing treatment strategies for stress-related diseases.

How is the Human ADRA1A Stable Cell Line-U2OS applied in studying the role of ADRA1A in cardiovascular diseases?

A: The Human ADRA1A Stable Cell Line-U2OS provides an experimental model for studying the role of ADRA1A in cardiovascular diseases. Through this cell line, scientists can investigate how ADRA1A affects the function of the heart and blood vessels, which is crucial for understanding the pathogenesis of cardiovascular diseases and developing new treatment strategies.

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