ODN 1668

Name: ODN 1668
SKU: CGON-07
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CGON-07

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Product Information

Cat. No.	CGON-07
Description	CpG oligodeoxynucleotides (or CpG ODNs) are synthetic oligonucleotides that contain unmethylated CpG motifs. CpG ODN can bind to and activate a Toll-like receptor 9 (TLR9) and leading to strong immunostimulatory effects. So far 3 major classes of CpG ODNs have been identified, based on their structural and biological characteristics, and are designated Type A, Type B, and Type C. Type A ODNs, which feature a central palindromic CpG-containing phosphodiester (PO) structure followed by a phosphorothioate (PS) homopolymeric G-stretch, are robust inducers of interferon-α (IFN-α) production and dendritic cell maturation. Type B ODNs, in contrast, contain a full phosphorothioate backbone with one or more CpG dinucleotides. They strongly activate B cells but stimulate weakly IFN-α secretion. Type C ODNs, combine the properties of both Type A and B, and are characterized by their complete PS backbone and palindromic CpG-containing motifs. Type C ODNs induce strong IFN-α production from pDC and B cell stimulation. ODN 1668 is a type B CpG ODN specific for murine TLR9.
Features	• Classification: Type B • Product format: Lyophilized product • Sequence: 5'-tccatgacgttcctgatgct-3' (lower case letters are phosphorothioate) • Specificity: Mouse, Rat
Storage	Store lyophilized product at -20°C. Upon reconstitution, aliquots should be stored at -20°C and are stable for 6 months. Avoid repeated freeze-thaw cycles.

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Customer Q&As

What is the activator for ODN 1668?

A: ODN 1668 is a mouse TLR9 agonist and exhibits good specificity.

What is the working concentration of ODN 1668?

A: The working concentration of ODN 1668 is 1-5μM.

What is the solubility of ODN 1668 in water?

A: ODN 1668 has a solubility of 5 mg/ml in water.

What is the sequence of ODN 1668?

A: The sequence of ODN 1668 is: 5'-tccatgacgttcctgatgct-3' (20 mer).

How is the quality control of ODN 1668 maintained?

A: ODN 1668 has undergone rigorous quality control, and it has been confirmed to be free from bacterial contamination (e.g., lipoproteins and endotoxins) using HEK-Blue TLR2 and HEK-Blue™ TLR4 cells.

What is the status of ODN 1668 upon receipt?

A: ODN 1668 is supplied in lyophilized form.

How many different specifications are available for ODN 1668?

A: ODN 1668 is available in three quantities: 200 μg (31.42 nmol), 1 mg (157.1 nmol), and 5 mg (785.5 nmol).

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