ODN 2216

Name: ODN 2216
SKU: CGON-02
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CGON-02

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Product Information

Cat. No.	CGON-02
Description	CpG oligodeoxynucleotides (or CpG ODNs) are synthetic oligonucleotides that contain unmethylated CpG motifs. CpG ODN can bind to and activate a Toll-like receptor 9 (TLR9) and leading to strong immunostimulatory effects. So far 3 major classes of CpG ODNs have been identified, based on their structural and biological characteristics, and are designated Type A, Type B, and Type C. Type A ODNs, which feature a central palindromic CpG-containing phosphodiester (PO) structure followed by a phosphorothioate (PS) homopolymeric G-stretch, are robust inducers of interferon-α (IFN-α) production and dendritic cell maturation. Type B ODNs, in contrast, contain a full phosphorothioate backbone with one or more CpG dinucleotides. They strongly activate B cells but stimulate weakly IFN-α secretion. Type C ODNs, combine the properties of both Type A and B, and are characterized by their complete PS backbone and palindromic CpG-containing motifs. Type C ODNs induce strong IFN-α production from pDC and B cell stimulation. ODN 2216 is a type A CpG ODN with a preference for human TLR9.
Features	• Classification: Type A • Product format: Lyophilized product • Sequence: 5'-ggGGGACGATCGTCgggggg-3' (lower case letters are phosphorothioate) • Specificity: Human, Mouse, Rat
Storage	Store lyophilized product at -20°C. Upon reconstitution, aliquots should be stored at -20°C and are stable for 6 months. Avoid repeated freeze-thaw cycles.

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What is the source of ODN 2216, and how is it synthesized?

A: ODN 2216 is typically synthesized using chemical synthesis methods, utilizing nucleotide monomers and solid-phase synthesis techniques. Its sequence and structure can be customized based on research needs.

What are the primary research fields in which ODN 2216 is applied?

A: ODN 2216 is primarily applied in the fields of immunology and immunotherapy, especially in modulating immune responses, inflammation research, and cancer therapy.

How does ODN 2216 exert its immunomodulatory effects?

A: ODN 2216 is generally considered an immunostimulant that activates the Toll-like Receptor 9 (TLR9) pathway, inducing immune cells to produce inflammatory mediators and interferons, thereby enhancing immune responses.

How is the concentration and dosage of ODN 2216 determined for experiments?

A: Determining the concentration and dosage of ODN 2216 typically involves initial experiments and concentration-response curve analysis to ensure optimization of experimental conditions and accurate dose selection.

What are the storage conditions and stability of ODN 2216?

A: ODN 2216 should be stored under freezing conditions, typically at -20°C or lower, to ensure its stability. Avoiding frequent freeze-thaw cycles is essential to reduce degradation.

In immunotherapy research, how is ODN 2216 used to enhance immune responses?

A: In immunotherapy research, ODN 2216 is commonly used to enhance anti-cancer immune responses. It can activate immune cells, enhance antigen presentation, and cytotoxicity.

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