ODN 5328

Name: ODN 5328
SKU: CGON-21
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CGON-21

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Product Information

Cat. No.	CGON-21
Description	CpG oligodeoxynucleotides (or CpG ODNs) are synthetic oligonucleotides that contain unmethylated CpG motifs. CpG ODN can bind to and activate a Toll-like receptor 9 (TLR9) and leading to strong immunostimulatory effects. So far 3 major classes of CpG ODNs have been identified, based on their structural and biological characteristics, and are designated Type A, Type B, and Type C. Type A ODNs, which feature a central palindromic CpG-containing phosphodiester (PO) structure followed by a phosphorothioate (PS) homopolymeric G-stretch, are robust inducers of interferon-α (IFN-α) production and dendritic cell maturation. Type B ODNs, in contrast, contain a full phosphorothioate backbone with one or more CpG dinucleotides. They strongly activate B cells but stimulate weakly IFN-α secretion. Type C ODNs, combine the properties of both Type A and B, and are characterized by their complete PS backbone and palindromic CpG-containing motifs. Type C ODNs induce strong IFN-α production from pDC and B cell stimulation. ODN 5328 can be used as a control for ODN 2395.
Features	• Classification: Type C control • Product format: Lyophilized product • Sequence: 5'-tgctgcttttcggcgcgcgccg-3' (lower case letters are phosphorothioate) • Specificity: Control for ODN 2395
Storage	Store lyophilized product at -20°C. Upon reconstitution, aliquots should be stored at -20°C and are stable for 6 months. Avoid repeated freeze-thaw cycles.

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Is there any relationship between ODN 5328 and ODN 2395?

A: ODN 5328 (ODN 2395 Control) can be used as a control for ODN 2395. ODN 5328 is similar in sequence to ODN 2395 but contains GpC dinucleotides instead of CpG motifs.

What are the shipping conditions for ODN 5328?

A: The storage condition for the continental United States is room temperature; it may vary for other regions.

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