ODN 2006

Name: ODN 2006
SKU: CGON-09
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CGON-09

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Product Information

Cat. No.	CGON-09
Description	CpG oligodeoxynucleotides (or CpG ODNs) are synthetic oligonucleotides that contain unmethylated CpG motifs. CpG ODN can bind to and activate a Toll-like receptor 9 (TLR9) and leading to strong immunostimulatory effects. So far 3 major classes of CpG ODNs have been identified, based on their structural and biological characteristics, and are designated Type A, Type B, and Type C. Type A ODNs, which feature a central palindromic CpG-containing phosphodiester (PO) structure followed by a phosphorothioate (PS) homopolymeric G-stretch, are robust inducers of interferon-α (IFN-α) production and dendritic cell maturation. Type B ODNs, in contrast, contain a full phosphorothioate backbone with one or more CpG dinucleotides. They strongly activate B cells but stimulate weakly IFN-α secretion. Type C ODNs, combine the properties of both Type A and B, and are characterized by their complete PS backbone and palindromic CpG-containing motifs. Type C ODNs induce strong IFN-α production from pDC and B cell stimulation. ODN 2006 is a type B CpG ODN with a preference for human TLR9.
Features	• Classification: Type B • Product format: Lyophilized product • Sequence: 5'-tcgtcgttttgtcgttttgtcgtt-3' (lower case letters are phosphorothioate) • Specificity: Human, Mouse, Rat
Storage	Store lyophilized product at -20°C. Upon reconstitution, aliquots should be stored at -20°C and are stable for 6 months. Avoid repeated freeze-thaw cycles.

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Customer Q&As

What type of CpG ODN is ODN 2006?

A: ODN 2006 is a type of B-class CpG ODN.

Which receptor does ODN 2006 act on?

A: ODN 2006 acts on Toll-like receptor 9 (TLR9) and has a preference for human TLR9.

Can it act on HD11 cells?

A: Yes, this reagent can stimulate HD11 cells to produce NO2 and IL-6.

What is the coding gene sequence of this product?

A: The coding sequence is: 5'-tcgtcgttttgtcgttttgtcgtt-3'.

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Customer Reviews

Activation of B cells

We successfully strongly activated B cells in mice using this reagent.

United States

2022-01-27

Very low endotoxin content

The ODN 2006 is prepared under strict sterile conditions, and the endotoxin content is very low.

Germany

2022-07-19

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ODN 2006

Product Information

Q & A

Customer Reviews

What type of CpG ODN is ODN 2006?

Which receptor does ODN 2006 act on?

Can it act on HD11 cells?

What is the coding gene sequence of this product?

Activation of B cells

Very low endotoxin content

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