ODN D-SL01

Name: ODN D-SL01
SKU: CGON-12
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CGON-12

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Product Information

Cat. No.	CGON-12
Description	CpG oligodeoxynucleotides (or CpG ODNs) are synthetic oligonucleotides that contain unmethylated CpG motifs. CpG ODN can bind to and activate a Toll-like receptor 9 (TLR9) and leading to strong immunostimulatory effects. So far 3 major classes of CpG ODNs have been identified, based on their structural and biological characteristics, and are designated Type A, Type B, and Type C. Type A ODNs, which feature a central palindromic CpG-containing phosphodiester (PO) structure followed by a phosphorothioate (PS) homopolymeric G-stretch, are robust inducers of interferon-α (IFN-α) production and dendritic cell maturation. Type B ODNs, in contrast, contain a full phosphorothioate backbone with one or more CpG dinucleotides. They strongly activate B cells but stimulate weakly IFN-α secretion. Type C ODNs, combine the properties of both Type A and B, and are characterized by their complete PS backbone and palindromic CpG-containing motifs. Type C ODNs induce strong IFN-α production from pDC and B cell stimulation. ODN D-SL01 is a type B CpG ODN for multispecies TLR9.
Features	• Classification: Type B • Product format: Lyophilized product • Sequence: 5'-tcgcgacgttcgcccgacgttcggta-3' (lower case letters are phosphorothioate) • Specificity: Multispecies
Storage	Store lyophilized product at -20°C. Upon reconstitution, aliquots should be stored at -20°C and are stable for 6 months. Avoid repeated freeze-thaw cycles.

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What is the sequence of ODN D-SL01?

A: 5'-T-C-G-C-G-A-C-G-T-T-C-G-C-C-C-G-A-C-G-T-T-C-G-G-T-A-3'.

How should ODN D-SL01 be stored?

A: -20°C, store sealed, away from moisture.

What type of nucleotide is ODN D-SL01?

A: ODN D-SL01 is a Class B CpG ODN (oligodeoxynucleotide) and is a TLR9 agonist.

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