ODN 684

Name: ODN 684
SKU: CGON-11
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CGON-11

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Cat. No.	CGON-11
Description	CpG oligodeoxynucleotides (or CpG ODNs) are synthetic oligonucleotides that contain unmethylated CpG motifs. CpG ODN can bind to and activate a Toll-like receptor 9 (TLR9) and leading to strong immunostimulatory effects. So far 3 major classes of CpG ODNs have been identified, based on their structural and biological characteristics, and are designated Type A, Type B, and Type C. Type A ODNs, which feature a central palindromic CpG-containing phosphodiester (PO) structure followed by a phosphorothioate (PS) homopolymeric G-stretch, are robust inducers of interferon-α (IFN-α) production and dendritic cell maturation. Type B ODNs, in contrast, contain a full phosphorothioate backbone with one or more CpG dinucleotides. They strongly activate B cells but stimulate weakly IFN-α secretion. Type C ODNs, combine the properties of both Type A and B, and are characterized by their complete PS backbone and palindromic CpG-containing motifs. Type C ODNs induce strong IFN-α production from pDC and B cell stimulation. ODN 684 is a type B CpG ODN specific for human / murine TLR9.
Features	• Classification: Type B • Product format: Lyophilized product • Sequence: 5'-tcgacgttcgtcgttcgtcgttc-3' (lower case letters are phosphorothioate) • Specificity: Human, Murine
Storage	Store lyophilized product at -20°C. Upon reconstitution, aliquots should be stored at -20°C and are stable for 6 months. Avoid repeated freeze-thaw cycles.

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How to store the reagents after dissolution?

A: It is recommended to divide the solution into aliquots according to the need after dissolution, store at -20°C, and avoid repeated freeze-thaw cycles.

Which CpG ODN is this reagent?

A: The reagent is a type B ODN, which, compared to type A, contains a complete phosphorothioate backbone and has one or more CpG dinucleotides.

Can it stimulate the secretion of IFN-α?

A: Yes, it is possible. However, although it can strongly activate B cells, its secretion of IFN-α is weak.

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Customer Reviews

Mouse TLR9

The product was successfully used to activate Toll-like receptor 9 (TLR9) in mice and conduct related immune experiments.

United States

2022-03-25

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ODN 684

Product Information

Q & A

Customer Reviews

How to store the reagents after dissolution?

Which CpG ODN is this reagent?

Can it stimulate the secretion of IFN-α?

Mouse TLR9

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