Recombinant Human TNFRSF1B (C-Fc)

Name: Recombinant Human TNFRSF1B (C-Fc)
SKU: RP00593
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : RP00593 Tag : C-Fc

Expressed Region : Leu23-Asp257 Expression System : Human Cell

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Product Information

Gene Information

Cat. No.	RP00593
Description	Recombinant Human TNFRSF1B (C-Fc) is produced in our Human Cell expression system. The amino acid region expressed is Leu23-Asp257 with a Fc tag at the C terminus.
Species	Human
Tag	C-Fc
Mol Weight	51.9 KDa
Conjugate	Unconjugated
Format	Powder
Expressed Region	Leu23-Asp257
Expression System	Human Cell
Formulation	Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Purity	>95% as determined by SDS-PAGE. >90% as determined by SEC-MALS.
Endotoxin Level	< 1 EU/µg of protein by LAL method
Storage	Upon receipt, this product is stable for up to 6 months at temperatures below -70°C. Once reconstituted, the product is stable for up to 1 week at 4°C and up to 3 months at -20°C. Please avoid repeated freeze-thaw cycles.
Shipping	The product is shipped with ice packs. Upon receipt, store it immediately at the temperature recommended below.
Reconstitution	Always centrifuge tubes before opening. It is recommended to reconstitute the solution to a concentration above 100 μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Target Gene	TNFRSF1B
Background	The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways.
Synonyms	Tumor necrosis factor receptor superfamily member 1B; TNFRSF1B; Tumor necrosis factor receptor 2; TNF-R2; TNF-RII; Tumor necrosis factor receptor type II; p75; p80 TNF-alpha receptor; CD120b

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