Human PVR Stable Cell Line - MC38

Name: Human PVR Stable Cell Line - MC38
SKU: CSC-RO0872
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-RO0872

Host Cell : MC38 Size : >1x10⁶ frozen cells/vial

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Cell Line Information

Cell Culture Information

Safety and Packaging

Gene Information

Cat. No.	CSC-RO0872
Description	This cell line is engineered to stably overexpress human PVR.
Target Gene	PVR
Gene Species	Homo sapiens (Human)
Host Cell	MC38
Host Cell Species	Mus musculus (Mouse)
Applications	1. Studying the interactions between immune cells and cancer cells 2. Studying the mechanisms of resistance to immune checkpoint blockade 3. High-throughput screening 4. Drug target validation
Size	>1x10⁶ frozen cells/vial
Stability	Validated for at least 10 passages
Quality Control	Negative for bacteria, yeast, fungi and mycoplasma.
Storage	Liquid nitrogen
Shipping	Dry ice

Revival

Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media.

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

Gene Name	PVR poliovirus receptor [ Homo sapiens ]
Gene Symbol	PVR
Synonyms	PVR; poliovirus receptor; PVS; CD155; HVED; Necl 5; NECL5; nectin like 5; Tage4; nectin-like 5; nectin-like protein 5; TAGE4; Necl-5; FLJ25946;
GeneID	5817
Uni ProtID	P15151
mRNA Refseq	BC015542
Chromosome Location	19q13.2
Function	cell adhesion molecule binding; protein binding; receptor activity;
Pathway	Adaptive Immune System, organism-specific biosystem; Adherens junctions interactions, organism-specific biosystem; Cell adhesion molecules (CAMs), organism-specific biosystem; Cell adhesion molecules (CAMs), conserved biosystem; Cell junction organization, organism-specific biosystem; Cell-Cell communication, organism-specific biosystem; Cell-cell junction organization, organism-specific biosystem;
MIM	173850

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Q & A

Customer Reviews

Customer Q&As

Has gene editing been performed on Human PVR Stable Cell Line - MC38 for more precise research?

A: Yes, gene editing has been performed on Human PVR Stable Cell Line - MC38 to achieve precise control of the PVR gene, allowing for in-depth research into its role in tumor immunology.

Have experiments involving overexpression or inhibition of the PVR gene been conducted with Human PVR Stable Cell Line - MC38 to study its impact on immune responses?

A: Yes, experiments involving overexpression and inhibition of the PVR gene have been conducted with Human PVR Stable Cell Line - MC38 to study its impact on immune responses. These experiments contribute to a better understanding of the mechanism of action of PVR in immunotherapy.

Has Human PVR Stable Cell Line - MC38 been used to investigate immune suppression mechanisms in the tumor microenvironment?

A: Yes, Human PVR Stable Cell Line - MC38 has been used to investigate immune suppression mechanisms in the tumor microenvironment, including the interaction between PVR and immune cells.

How is the effectiveness of new immunotherapy drugs evaluated using Human PVR Stable Cell Line - MC38?

A: The effectiveness of new immunotherapy drugs is typically evaluated using Human PVR Stable Cell Line - MC38 through experiments such as electrophysiological recordings of channel activity and calcium imaging. These experiments assess the impact of drugs on PVR function.

How is potential cell toxicity or adaptation issues addressed when working with Human PVR Stable Cell Line - MC38?

A: Addressing potential cell toxicity or adaptation issues when working with Human PVR Stable Cell Line - MC38 may require optimization of culture conditions, selection of suitable culture media, and the addition of appropriate cell factors to ensure cell health and adaptation.

Have mouse models related to Human PVR Stable Cell Line - MC38 been developed to further investigate the function of PVR?

A: Yes, mouse models related to Human PVR Stable Cell Line - MC38 have been developed to further investigate the function of PVR and tumor immunology mechanisms.

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