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Cat.No. : CSC-RO0872 Host Cell: MC38
| Cat. No. | CSC-RO0872 |
| Description | This cell line is engineered to stably overexpress human PVR. |
| Gene | PVR |
| Gene Species | Homo sapiens (Human) |
| Host Cell | MC38 |
| Host Cell Species | Mus musculus (Mouse) |
| Stability | Validated for at least 10 passages |
| Application | 1. Studying the interactions between immune cells and cancer cells 2. Studying the mechanisms of resistance to immune checkpoint blockade 3. High-throughput screening 4. Drug target validation |
| Quality Control | Negative for bacteria, yeast, fungi and mycoplasma. |
| Shipping | Dry ice |
| Storage | Liquid nitrogen |
| Revival | Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media. |
| Mycoplasma | Negative |
| Format | One frozen vial containing millions of cells |
| Storage | Liquid nitrogen |
| Safety Considerations |
The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach. |
| Ship | Dry ice |
A: Yes, gene editing has been performed on Human PVR Stable Cell Line - MC38 to achieve precise control of the PVR gene, allowing for in-depth research into its role in tumor immunology.
A: Yes, experiments involving overexpression and inhibition of the PVR gene have been conducted with Human PVR Stable Cell Line - MC38 to study its impact on immune responses. These experiments contribute to a better understanding of the mechanism of action of PVR in immunotherapy.
A: Yes, Human PVR Stable Cell Line - MC38 has been used to investigate immune suppression mechanisms in the tumor microenvironment, including the interaction between PVR and immune cells.
A: The effectiveness of new immunotherapy drugs is typically evaluated using Human PVR Stable Cell Line - MC38 through experiments such as electrophysiological recordings of channel activity and calcium imaging. These experiments assess the impact of drugs on PVR function.
A: Addressing potential cell toxicity or adaptation issues when working with Human PVR Stable Cell Line - MC38 may require optimization of culture conditions, selection of suitable culture media, and the addition of appropriate cell factors to ensure cell health and adaptation.
A: Yes, mouse models related to Human PVR Stable Cell Line - MC38 have been developed to further investigate the function of PVR and tumor immunology mechanisms.
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