Human PVR Stable Cell Line - CT26

Name: Human PVR Stable Cell Line - CT26
SKU: CSC-RO0877
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-RO0877

Host Cell : CT26 Size : >1x10⁶ frozen cells/vial

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Cell Line Information

Cell Culture Information

Safety and Packaging

Gene Information

Cat. No.	CSC-RO0877
Description	This cell line is engineered to stably overexpress human PVR.
Target Gene	PVR
Gene Species	Homo sapiens (Human)
Host Cell	CT26
Host Cell Species	Mus musculus (Mouse)
Applications	1. Studying the interactions between immune cells and cancer cells 2. Studying the mechanisms of resistance to immune checkpoint blockade 3. High-throughput screening 4. Drug target validation
Size	>1x10⁶ frozen cells/vial
Stability	Validated for at least 10 passages
Quality Control	Negative for bacteria, yeast, fungi and mycoplasma.
Storage	Liquid nitrogen
Shipping	Dry ice

Revival

Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media.

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

Gene Name	PVR poliovirus receptor [ Homo sapiens ]
Gene Symbol	PVR
Synonyms	PVR; poliovirus receptor; PVS; CD155; HVED; Necl 5; NECL5; nectin like 5; Tage4; nectin-like 5; nectin-like protein 5; TAGE4; Necl-5; FLJ25946;
GeneID	5817
Uni ProtID	P15151
mRNA Refseq	BC015542
Chromosome Location	19q13.2
Function	cell adhesion molecule binding; protein binding; receptor activity;
Pathway	Adaptive Immune System, organism-specific biosystem; Adherens junctions interactions, organism-specific biosystem; Cell adhesion molecules (CAMs), organism-specific biosystem; Cell adhesion molecules (CAMs), conserved biosystem; Cell junction organization, organism-specific biosystem; Cell-Cell communication, organism-specific biosystem; Cell-cell junction organization, organism-specific biosystem;
MIM	173850

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Q & A

Customer Reviews

Customer Q&As

How is the Human PVR Stable Cell Line applied in simulating the tumor microenvironment?

A: Useful in simulating the tumor microenvironment to study the effects of PVR on tumor cell survival and proliferation.

What is the uniqueness of the Human PVR Stable Cell Line in cellular immunology research?

A: This cell line is particularly suited for studying the role of PVR in interactions between tumor cells and the immune system.

What role does the Human PVR Stable Cell Line play in anti-tumor drug screening?

A: Used for screening and evaluating drugs targeting PVR, especially in cancer treatments and immune checkpoint therapies.

What are the important considerations when culturing the Human PVR Stable Cell Line?

A: Attention should be given to culture conditions such as the choice of medium, temperature, and CO2 levels to ensure stable cell growth and PVR expression.

What are the primary research applications of the Human PVR Stable Cell Line - CT26?

A: Mainly used in immunotherapy research, particularly in assessing PVR as a potential target for anti-tumor treatments.

What is the background and origin of the Human PVR Stable Cell Line - CT26?

A: The Human PVR Stable Cell Line - CT26 is developed based on the CT26 cell line. This cell line is established by overexpressing the human PVR (CD155) gene.

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