Human LILRB4 Stable Cell Line - BaF3

Name: Human LILRB4 Stable Cell Line - BaF3
SKU: CSC-RO0846
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-RO0846

Host Cell : Ba/F3 Size : >1x10⁶ frozen cells/vial

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Cell Line Information

Cell Culture Information

Safety and Packaging

Gene Information

Cat. No.	CSC-RO0846
Description	This cell line is engineered to stably overexpress human LILRB4.
Target Gene	LILRB4
Gene Species	Homo sapiens (Human)
Host Cell	Ba/F3
Host Cell Species	Mus musculus (Mouse)
Applications	1. Studying the interactions between immune cells and cancer cells 2. Studying the mechanisms of resistance to immune checkpoint blockade 3. High-throughput screening 4. Drug target validation
Size	>1x10⁶ frozen cells/vial
Stability	Validated for at least 10 passages
Quality Control	Negative for bacteria, yeast, fungi and mycoplasma.
Storage	Liquid nitrogen
Shipping	Dry ice

Revival

Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media.

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

Gene Name	LILRB4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4 [ Homo sapiens ]
Gene Symbol	LILRB4
Synonyms	HM18; ILT3; LIR5; CD85K; LIR-5; LILRB5
Gene Description	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
Gene ID	11006
Uni Prot ID	Q8NHJ6
m RNA Refseq	NM_006847.3
Protein Refseq	NP_006838.3
Chromosome Location	19q13.4
Function	antigen binding; protein binding; receptor activity;
Pathway	Adaptive Immune System, organism-specific biosystem; Immune System, organism-specific biosystem; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystem; Osteoclast differentiation, organism-specific biosystem; Osteoclast differentiation, conserved biosystem;
MIM	604821

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Q & A

Customer Reviews

Customer Q&As

What is the origin of the Human LILRB4 Stable Cell Line - BaF3?

A: The Human LILRB4 Stable Cell Line - BaF3 combines the Ba/F3 cell line with the human LILRB4 gene. Ba/F3 is a murine pre-B cell line dependent on interleukin-3 (IL-3) for growth. The LILRB4 gene is part of the leukocyte immunoglobulin-like receptor (LIR) family and is expressed in monocytes to regulate immune responses.

What are the main research areas for the Human LILRB4 Stable Cell Line - BaF3?

A: The Human LILRB4 Stable Cell Line - BaF3 is primarily used in cancer immunotherapy research. LILRB4 is expressed in tumor-associated macrophages, influencing tumor immune responses. The Ba/F3 cell line is used for kinase drug discovery and studying cell survival mechanisms.

What are the considerations when using this cell line?

A: When using the Human LILRB4 Stable Cell Line - BaF3, it's important to consider its dependency on IL-3 and its reactivity to specific kinases. Cell growth conditions must ensure sufficient IL-3, while monitoring the functionality of LILRB4 and its response to drugs.

How is the potential of this cell line in cancer immunotherapy evaluated?

A: The Human LILRB4 Stable Cell Line - BaF3 has significant potential in cancer immunotherapy, especially as a model for testing novel immunotherapies. The LILRB4 gene plays a crucial role in regulating tumor immune responses, and its expression in the tumor microenvironment is closely associated with disease severity and patient survival.

What are the applications of the LILRB4 gene in cancer treatment?

A: The LILRB4 gene serves as an immune checkpoint receptor in cancer treatment, regulating immune responses by inhibiting T cells. This makes it a potential target for cancer immunotherapy, particularly for solid tumors.

What implications does this cell line have for future cancer research?

A: The Human LILRB4 Stable Cell Line - BaF3 provides a vital tool for studying the role of LILRB4 in cancer immune regulation. It helps understand how LILRB4 functions in the tumor microenvironment, thereby advancing the development of cancer immunotherapy strategies.

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