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Cat.No. : CSC-RO0846 Host Cell: BaF3
| Cat. No. | CSC-RO0846 |
| Description | This cell line is engineered to stably overexpress human LILRB4. |
| Gene | LILRB4 |
| Gene Species | Homo sapiens (Human) |
| Host Cell | BaF3 |
| Host Cell Species | Mus musculus (Mouse) |
| Stability | Validated for at least 10 passages |
| Application | 1. Studying the interactions between immune cells and cancer cells 2. Studying the mechanisms of resistance to immune checkpoint blockade 3. High-throughput screening 4. Drug target validation |
| Quality Control | Negative for bacteria, yeast, fungi and mycoplasma. |
| Shipping | Dry ice |
| Storage | Liquid nitrogen |
| Revival | Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media. |
| Mycoplasma | Negative |
| Format | One frozen vial containing millions of cells |
| Storage | Liquid nitrogen |
| Safety Considerations |
The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach. |
| Ship | Dry ice |
A: The Human LILRB4 Stable Cell Line - BaF3 combines the Ba/F3 cell line with the human LILRB4 gene. Ba/F3 is a murine pre-B cell line dependent on interleukin-3 (IL-3) for growth. The LILRB4 gene is part of the leukocyte immunoglobulin-like receptor (LIR) family and is expressed in monocytes to regulate immune responses.
A: The Human LILRB4 Stable Cell Line - BaF3 is primarily used in cancer immunotherapy research. LILRB4 is expressed in tumor-associated macrophages, influencing tumor immune responses. The Ba/F3 cell line is used for kinase drug discovery and studying cell survival mechanisms.
A: When using the Human LILRB4 Stable Cell Line - BaF3, it's important to consider its dependency on IL-3 and its reactivity to specific kinases. Cell growth conditions must ensure sufficient IL-3, while monitoring the functionality of LILRB4 and its response to drugs.
A: The Human LILRB4 Stable Cell Line - BaF3 has significant potential in cancer immunotherapy, especially as a model for testing novel immunotherapies. The LILRB4 gene plays a crucial role in regulating tumor immune responses, and its expression in the tumor microenvironment is closely associated with disease severity and patient survival.
A: The LILRB4 gene serves as an immune checkpoint receptor in cancer treatment, regulating immune responses by inhibiting T cells. This makes it a potential target for cancer immunotherapy, particularly for solid tumors.
A: The Human LILRB4 Stable Cell Line - BaF3 provides a vital tool for studying the role of LILRB4 in cancer immune regulation. It helps understand how LILRB4 functions in the tumor microenvironment, thereby advancing the development of cancer immunotherapy strategies.
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