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Cat.No. : CSC-RO0900 Host Cell: C1498
| Cat. No. | CSC-RO0900 |
| Description | This cell line is engineered to stably overexpress human LILRB4. |
| Gene | LILRB4 |
| Gene Species | Homo sapiens (Human) |
| Host Cell | C1498 |
| Host Cell Species | Mus musculus (Mouse) |
| Stability | Validated for at least 10 passages |
| Application | 1. Studying the interactions between immune cells and cancer cells 2. Studying the mechanisms of resistance to immune checkpoint blockade 3. High-throughput screening 4. Drug target validation |
| Quality Control | Negative for bacteria, yeast, fungi and mycoplasma. |
| Shipping | Dry ice |
| Storage | Liquid nitrogen |
| Revival | Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media. |
| Mycoplasma | Negative |
| Format | One frozen vial containing millions of cells |
| Storage | Liquid nitrogen |
| Safety Considerations |
The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach. |
| Ship | Dry ice |
A: The Human LILRB4 Stable Cell Line - C1498 is derived from the C1498 cell line. C1498 is a murine primary leukemia cell line that has undergone a series of cell engineering procedures, including the introduction of the human LILRB4 (Leukocyte Immunoglobulin-Like Receptor B4) gene, to establish this specific cell line.
A: The primary purpose of the Human LILRB4 Stable Cell Line - C1498 is for researching immunological and cell biology questions related to the human LILRB4 receptor. This cell line can be used to study the role of LILRB4 in regulating immune responses, inhibiting inflammatory reactions, and influencing tumor immune evasion, among other functions.
A: LILRB4 is an immunoglobulin-like receptor primarily expressed on immune cells such as monocytes, macrophages, and dendritic cells. Its main functions include regulating immune responses, suppressing inflammatory reactions, and playing a role in tumor immune evasion. Researching LILRB4 using a stable cell line is essential for gaining a deeper understanding of the receptor's function and mechanisms, as it allows scientists to conduct controlled experiments to elucidate the precise roles of LILRB4 in immune regulation and tumor immunity.
A: The Human LILRB4 Stable Cell Line - C1498 is typically used for studying the role of LILRB4 in immune regulation, immune evasion, and inflammation control. These cells can be used in in vitro experiments such as cell proliferation, apoptosis, cell migration, and other functional assays. Furthermore, they can be employed to investigate the interactions of LILRB4 with other proteins or molecules, shedding light on its signaling pathways.
A: LILRB4 may play a significant role in leukemia research, particularly concerning the C1498 cell line, which originates from murine leukemia. Studying the function of LILRB4 in this context can help understand its role in the onset and progression of leukemia and potential therapeutic targets. Additionally, it can be used to explore LILRB4 expression and function in human leukemia patients.
A: LILRB4 plays a crucial role in tumor immune evasion. It can bind to ligands such as HLA-G on the surface of immune cells, inhibiting their activation and anti-tumor effects, thereby assisting tumor cells in evading immune surveillance and clearance. Investigating the role of LILRB4 in this process can lead to the development of novel immunotherapies and treatment strategies to enhance the immune system's response to tumors.
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