Human LILRB4 Stable Cell Line - C1498

Name: Human LILRB4 Stable Cell Line - C1498
SKU: CSC-RO0900
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-RO0900

Host Cell : C1498 Size : >1x10⁶ frozen cells/vial

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Cell Line Information

Cell Culture Information

Safety and Packaging

Gene Information

Cat. No.	CSC-RO0900
Description	This cell line is engineered to stably overexpress human LILRB4.
Target Gene	LILRB4
Gene Species	Homo sapiens (Human)
Host Cell	C1498
Host Cell Species	Mus musculus (Mouse)
Applications	1. Studying the interactions between immune cells and cancer cells 2. Studying the mechanisms of resistance to immune checkpoint blockade 3. High-throughput screening 4. Drug target validation
Size	>1x10⁶ frozen cells/vial
Stability	Validated for at least 10 passages
Quality Control	Negative for bacteria, yeast, fungi and mycoplasma.
Storage	Liquid nitrogen
Shipping	Dry ice

Revival

Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media.

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

Gene Name	LILRB4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4 [ Homo sapiens ]
Gene Symbol	LILRB4
Synonyms	HM18; ILT3; LIR5; CD85K; LIR-5; LILRB5
Gene Description	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
Gene ID	11006
Uni Prot ID	Q8NHJ6
m RNA Refseq	NM_006847.3
Protein Refseq	NP_006838.3
Chromosome Location	19q13.4
Function	antigen binding; protein binding; receptor activity;
Pathway	Adaptive Immune System, organism-specific biosystem; Immune System, organism-specific biosystem; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystem; Osteoclast differentiation, organism-specific biosystem; Osteoclast differentiation, conserved biosystem;
MIM	604821

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Q & A

Customer Reviews

Customer Q&As

What is the origin of the Human LILRB4 Stable Cell Line - C1498, and how was it established?

A: The Human LILRB4 Stable Cell Line - C1498 is derived from the C1498 cell line. C1498 is a murine primary leukemia cell line that has undergone a series of cell engineering procedures, including the introduction of the human LILRB4 (Leukocyte Immunoglobulin-Like Receptor B4) gene, to establish this specific cell line.

What is the primary purpose of the Human LILRB4 Stable Cell Line - C1498?

A: The primary purpose of the Human LILRB4 Stable Cell Line - C1498 is for researching immunological and cell biology questions related to the human LILRB4 receptor. This cell line can be used to study the role of LILRB4 in regulating immune responses, inhibiting inflammatory reactions, and influencing tumor immune evasion, among other functions.

What is the function of LILRB4 in the immune system, and why is a stable cell line for its research essential?

A: LILRB4 is an immunoglobulin-like receptor primarily expressed on immune cells such as monocytes, macrophages, and dendritic cells. Its main functions include regulating immune responses, suppressing inflammatory reactions, and playing a role in tumor immune evasion. Researching LILRB4 using a stable cell line is essential for gaining a deeper understanding of the receptor's function and mechanisms, as it allows scientists to conduct controlled experiments to elucidate the precise roles of LILRB4 in immune regulation and tumor immunity.

How is the Human LILRB4 Stable Cell Line - C1498 used in experiments?

A: The Human LILRB4 Stable Cell Line - C1498 is typically used for studying the role of LILRB4 in immune regulation, immune evasion, and inflammation control. These cells can be used in in vitro experiments such as cell proliferation, apoptosis, cell migration, and other functional assays. Furthermore, they can be employed to investigate the interactions of LILRB4 with other proteins or molecules, shedding light on its signaling pathways.

What is the role of LILRB4 in leukemia research?

A: LILRB4 may play a significant role in leukemia research, particularly concerning the C1498 cell line, which originates from murine leukemia. Studying the function of LILRB4 in this context can help understand its role in the onset and progression of leukemia and potential therapeutic targets. Additionally, it can be used to explore LILRB4 expression and function in human leukemia patients.

What is the role of LILRB4 in tumor immune evasion?

A: LILRB4 plays a crucial role in tumor immune evasion. It can bind to ligands such as HLA-G on the surface of immune cells, inhibiting their activation and anti-tumor effects, thereby assisting tumor cells in evading immune surveillance and clearance. Investigating the role of LILRB4 in this process can lead to the development of novel immunotherapies and treatment strategies to enhance the immune system's response to tumors.

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