Human INSR Stable Cell Line - CHO-K1

Name: Human INSR Stable Cell Line - CHO-K1
SKU: CSC-RO0465
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-RO0465

Host Cell : CHO-K1 Size : >1x10⁶ frozen cells/vial

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Cell Line Information

Cell Culture Information

Safety and Packaging

Gene Information

Cat. No.	CSC-RO0465
Description	This cell line is derived from CHO-K1 and is engineered to stably overexpress Human INSR.
Target Gene	INSR
Gene Species	Homo sapiens (Human)
Host Cell	CHO-K1
Host Cell Species	Cricetulus griseus (Chinese hamster)
Applications	1. Studying the interactions between immune cells and cancer cells 2. Studying the mechanisms of resistance to immune checkpoint blockade 3. High-throughput screening 4. Drug target validation
Size	>1x10⁶ frozen cells/vial
Stability	Validated for at least 10 passages
Quality Control	Negative for bacteria, yeast, fungi and mycoplasma.
Storage	Liquid nitrogen
Shipping	Dry ice

Revival

Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media.

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

Gene Name	INSR insulin receptor [ Homo sapiens ]
Gene Symbol	INSR
Synonyms	HHF5; CD220
Gene Description	insulin receptor
Gene ID	3643
Uni Prot ID	P06213
m RNA Refseq	NM_001079817.1
Protein Refseq	NP_001073285.1
Chromosome Location	19p13.3-p13.2
Function	3-phosphoinositide-dependent protein kinase binding; ATP binding; GTP binding; PTB domain binding; SH2 domain binding; insulin binding; insulin binding; insulin receptor substrate binding; insulin-activated receptor activity; insulin-like growth factor I binding; insulin-like growth factor II binding; insulin-like growth factor receptor binding; lipoic acid binding; phosphatidylinositol 3-kinase binding; protein binding; protein complex binding; protein phosphatase binding; protein tyrosine kinase activity; protein tyrosine kinase activity; receptor signaling protein tyrosine kinase activity;
Pathway	AMPK signaling, organism-specific biosystem; Adherens junction, organism-specific biosystem; Adherens junction, conserved biosystem; Aldosterone-regulated sodium reabsorption, organism-specific biosystem; Aldosterone-regulated sodium reabsorption, conserved biosystem; DNA damage response (only ATM dependent), organism-specific biosystem; HIF-1 signaling pathway, organism-specific biosystem;
MIM	147670

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