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Cat.No. : CSC-RO1033 Host Cell: HEK293T
| Cat. No. | CSC-RO1033 |
| Description | HEK293-CEACAM5 cell line is engineered to stably overexpress human CEACAM5. |
| Gene | CEACAM5 |
| Gene Species | Homo sapiens (Human) |
| Host Cell | HEK293T |
| Host Cell Species | Homo sapiens (Human) |
| Stability | Validated for at least 10 passages |
| Application | 1. Studying the interactions between immune cells and cancer cells 2. Studying the mechanisms of resistance to immune checkpoint blockade 3. High-throughput screening 4. Drug target validation |
| Quality Control | Negative for bacteria, yeast, fungi and mycoplasma. |
| Shipping | Dry ice |
| Storage | Liquid nitrogen |
| Revival | Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media. |
| Growth Properties | Cells are cultured as a monolayer at 37°C in a humidified atmosphere with 5% CO2. Split at 80-90% confluence, approximately 1:3-1:6. |
| Mycoplasma | Negative |
| Format | One frozen vial containing millions of cells |
| Storage | Liquid nitrogen |
| Safety Considerations |
The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach. |
| Ship | Dry ice |
A: Human CEACAM5 Stable Cell Line-HEK293 is characterized by high expression of CEACAM5, making it particularly suitable for studying gastrointestinal cancers, as this protein plays a crucial role in the development and progression of these cancers.
A: Human CEACAM5 Stable Cell Line-HEK293 can be used in the development of targeted therapies by facilitating the study of CEACAM5 interactions with therapeutic agents, thus providing insights into effective colorectal cancer treatments.
A: The expression profile of CEACAM5 in Human CEACAM5 Stable Cell Line-HEK293 is significantly upregulated compared to normal gastrointestinal tissues, mirroring the overexpression observed in gastrointestinal tumor cells.
A: Using Human CEACAM5 Stable Cell Line-HEK293, researchers can investigate the role of CEACAM5 in the metastatic process, potentially revealing novel mechanisms and targets for preventing or treating metastasis in gastrointestinal cancers.
A: Yes, Human CEACAM5 Stable Cell Line-HEK293 is well-suited for high-throughput screening, allowing researchers to efficiently test a large number of compounds for their efficacy in targeting CEACAM5 and inhibiting cancer cell proliferation.
A: Experiments with Human CEACAM5 Stable Cell Line-HEK293 require standard biosafety measures, including the use of biological safety cabinets, personal protective equipment, and proper waste disposal to ensure safety and prevent contamination.
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