Human CEACAM5 Stable Cell Line-HEK293T

Name: Human CEACAM5 Stable Cell Line-HEK293T
SKU: CSC-RO1033
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-RO1033

Host Cell : HEK293T Size : >1x10⁶ frozen cells/vial

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Cell Line Information

Cell Culture Information

Safety and Packaging

Gene Information

Cat. No.	CSC-RO1033
Description	HEK293-CEACAM5 cell line is engineered to stably overexpress human CEACAM5.
Target Gene	CEACAM5
Gene Species	Homo sapiens (Human)
Host Cell	HEK293T
Host Cell Species	Homo sapiens (Human)
Applications	1. Studying the interactions between immune cells and cancer cells 2. Studying the mechanisms of resistance to immune checkpoint blockade 3. High-throughput screening 4. Drug target validation
Size	>1x10⁶ frozen cells/vial
Stability	Validated for at least 10 passages
Quality Control	Negative for bacteria, yeast, fungi and mycoplasma.
Storage	Liquid nitrogen
Shipping	Dry ice

Revival	Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media.
Growth Properties	Cells are cultured as a monolayer at 37°C in a humidified atmosphere with 5% CO₂. Split at 80-90% confluence, approximately 1:3-1:6.

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

Gene Name	CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 [ Homo sapiens ]
Gene Symbol	CEACAM5
Synonyms	CEACAM5; carcinoembryonic antigen-related cell adhesion molecule 5; CEA; CD66e; meconium antigen 100; DKFZp781M2392;
Gene ID	1048
Uni Prot ID	P06731
m RNA Refseq	BC034671
Chromosome Location	19q13.1-q13.2
MIM	114890

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Q & A

Customer Reviews

Customer Q&As

What are the specific characteristics of Human CEACAM5 Stable Cell Line-HEK293 that make it suitable for studying gastrointestinal cancers?

A: Human CEACAM5 Stable Cell Line-HEK293 is characterized by high expression of CEACAM5, making it particularly suitable for studying gastrointestinal cancers, as this protein plays a crucial role in the development and progression of these cancers.

In what ways can Human CEACAM5 Stable Cell Line-HEK293 be utilized in the development of targeted therapies for colorectal cancer?

A: Human CEACAM5 Stable Cell Line-HEK293 can be used in the development of targeted therapies by facilitating the study of CEACAM5 interactions with therapeutic agents, thus providing insights into effective colorectal cancer treatments.

How does the expression profile of CEACAM5 in Human CEACAM5 Stable Cell Line-HEK293 compare to its expression in normal gastrointestinal tissues?

A: The expression profile of CEACAM5 in Human CEACAM5 Stable Cell Line-HEK293 is significantly upregulated compared to normal gastrointestinal tissues, mirroring the overexpression observed in gastrointestinal tumor cells.

What are the potential implications of using Human CEACAM5 Stable Cell Line-HEK293 in understanding the metastatic process of gastrointestinal cancers?

A: Using Human CEACAM5 Stable Cell Line-HEK293, researchers can investigate the role of CEACAM5 in the metastatic process, potentially revealing novel mechanisms and targets for preventing or treating metastasis in gastrointestinal cancers.

Can Human CEACAM5 Stable Cell Line-HEK293 be employed in high-throughput screening for anti-cancer drugs targeting CEACAM5?

A: Yes, Human CEACAM5 Stable Cell Line-HEK293 is well-suited for high-throughput screening, allowing researchers to efficiently test a large number of compounds for their efficacy in targeting CEACAM5 and inhibiting cancer cell proliferation.

What safety measures should be taken when conducting experiments with Human CEACAM5 Stable Cell Line-HEK293, considering its modified nature?

A: Experiments with Human CEACAM5 Stable Cell Line-HEK293 require standard biosafety measures, including the use of biological safety cabinets, personal protective equipment, and proper waste disposal to ensure safety and prevent contamination.

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