Human CD40LG Stable Cell Line - CHO-K1

CD40LG, also known as CD40 ligand, is the protein encoded by the CD40LG gene in humans. It is a member of the TNF receptor superfamily. This protein is expressed on the surface of T cells and regulates B cell function by binding to CD40 on the surface of B cells. This protein is critical for mediating multiple immune and inflammatory responses, including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. Mutations in this gene cause X-linked hyperIgM syndrome, a rare immunodeficiency characterized by defects in immunoglobulin class switch recombination. CD40LG has also been found to play an important role in various diseases including cancer and autoimmunity.

Human CD40LG Stable Cell Line - CHO-K1 is a cell line genetically engineered to stably express the CD40 ligand (CD40LG) protein found in humans. This particular cell line is derived from Chinese Hamster Ovary (CHO-K1) cells. The CD40LG-CHO-K1 cell line is particularly valuable for scientific research in immunology, inflammation, and cancer. Researchers can use this cell line to study the function of the CD40/CD40LG interaction, which is important for immune regulation and homeostasis.