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Rat Gpc3 ORF Clone(NM_012774.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDCR377634

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Product Information

Gene Information

Cat. No. CDCR377634
Product Type ORF Clone
Gene Abbr Gpc3
Species Rat
Tag C-terminal Myc-DDK
ORF Size 1794 bp
Vector pCMV6-Entry
Target Gene GPC3
Background Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The protein encoded by this gene can bind to and inhibit the dipeptidyl peptidase activity of CD26, and it can induce apoptosis in certain cell types. Deletion mutations in this gene are associated with Simpson-Golabi-Behmel syndrome, also known as Simpson dysmorphia syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]
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