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Human TLR6 Stable Cell Line-HEK293

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Cat.No.
CSC-RO0058
Cell Line Description
This cell line is a stably transfected cell line which expresses human Toll-like receptor 6 (TLR6) with an N-terminal HA tag.
Background
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor functionally interacts with toll-like receptor 2 to mediate cellular response to bacterial lipoproteins. A Ser249Pro polymorphism in the extracellular domain of the encoded protein may be associated with an increased of asthma is some populations.
Host Cell
HEK293
Ship
Dry ice
Antigen Gene Information
Official Symbol
TLR6
Synonyms
CD286
GeneID
UniProt ID
Q9Y2C9
Chromosome Location
4p14

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