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Cat.No. : CSC-RG0013 Host Cell: U2OS
| Cat. No. | CSC-RG0013 |
| Background | Tachykinin receptor 2 is the gene that encodes a protein that is one of the three Tachykinin receptors (TACRs), also termed NKRs. The Tachykinin receptor family is a group of G-coupled receptors whose principal ligands are the Neurokinins. TACR2 has been involved in stress induced hippocampal acetylcholine release and it is thought to be related with Alzheimer"s disease (AD). |
| Gene | TACR2 |
| Gene Species | Homo sapiens (Human) |
| Alias | TACR2, NK2R, NKNAR, SKR, TAC2R |
| Host Cell | U2OS |
| Species | Homo sapiens (Human) |
| Morphology | Epithelial |
| Stability | Validated for at least 10 passages |
| Application | 1. Gene expression studies 2. Signaling pathway research 3. Drug screening and toxicology 4. Research on the mechanisms of GPCR-related diseases |
| Quality Control | Negative for bacteria, yeast, fungi and mycoplasma. |
| Shipping | Dry ice |
| Storage | Liquid nitrogen |
| Revival | Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media. |
| Growth Properties | Adherent |
| Mycoplasma | Negative |
| Format | One frozen vial containing millions of cells |
| Storage | Liquid nitrogen |
| Safety Considerations |
The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach. |
| Ship | Dry ice |
A: The Human TACR2 Stable Cell Line-U2OS, established by stably expressing the human synaptic toxin receptor 2 (TACR2) in U2OS cells, plays a significant role in elucidating how neurotransmitters are released into the synaptic cleft through the TACR2 receptor. Researchers can simulate and observe the function of TACR2 in neural regulation using this cell line, which is crucial for understanding the pathological mechanisms of neurological diseases such as Parkinson's disease.
A: During drug screening, the Human TACR2 Stable Cell Line-U2OS can be used to evaluate the specificity of potential drugs for the TACR2 receptor. By measuring the binding affinity and functional effects of drugs on the TACR2 receptor, scientists can determine whether the drugs are selective, which is essential for developing therapeutic drugs targeting specific neurological diseases.
A: The Human TACR2 Stable Cell Line-U2OS can be used to study the role of TACR2 receptors in neurodegenerative diseases, such as Parkinson's and Alzheimer's disease. This cell line helps scientists understand the potential pathological role of TACR2 receptors in these diseases and develop potential therapeutic strategies targeting TACR2.
A: The Human TACR2 Stable Cell Line-U2OS provides a platform for studying the function of TACR2 receptors in neural transmission, including their roles at the presynaptic and postsynaptic sites. This cell line helps scientists uncover the specific mechanisms of action of TACR2 receptors in neural signal transmission, which is crucial for understanding the complex functions of the nervous system.
A: The Human TACR2 Stable Cell Line-U2OS can be used to study the role of TACR2 receptors in pain perception, particularly in the sensitivity of nerve endings. This cell line helps scientists understand how TACR2 receptors modulate the transmission of pain signals, which is significant for developing new pain management strategies.
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