Human TACR2 Stable Cell Line-U2OS

Name: Human TACR2 Stable Cell Line-U2OS
SKU: CSC-RG0013
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-RG0013

Host Cell : U2OS Size : >1x10⁶ frozen cells/vial

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Cell Line Information

Cell Culture Information

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Gene Information

Cat. No.	CSC-RG0013
Background	Tachykinin receptor 2 is the gene that encodes a protein that is one of the three Tachykinin receptors (TACRs), also termed NKRs. The Tachykinin receptor family is a group of G-coupled receptors whose principal ligands are the Neurokinins. TACR2 has been involved in stress induced hippocampal acetylcholine release and it is thought to be related with Alzheimer"s disease (AD).
Target Gene	TACR2
Gene Species	Homo sapiens (Human)
Abbr	U2OS-HuTACR2
Alias	TACR2, NK2R, NKNAR, SKR, TAC2R
Host Cell	U2OS
Host Cell Species	Homo sapiens (Human)
Applications	1. Gene expression studies 2. Signaling pathway research 3. Drug screening and toxicology 4. Research on the mechanisms of GPCR-related diseases
Size	>1x10⁶ frozen cells/vial
Stability	Validated for at least 10 passages
Quality Control	Negative for bacteria, yeast, fungi and mycoplasma.
Storage	Liquid nitrogen
Shipping	Dry ice

Revival	Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media.
Growth Properties	Adherent

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

Gene Name	TACR2 tachykinin receptor 2 [ Homo sapiens ]
Gene Symbol	TACR2
Synonyms	SKR; NK2R; NKNAR; TAC2R
Gene Description	tachykinin receptor 2
GeneID	6865
Uni ProtID	P21452
mRNA Refseq	NM_001057.2
Protein Refseq	NP_001048.2
Chromosome Location	10q22.1
Function	tachykinin receptor activity;
Pathway	Calcium signaling pathway, organism-specific biosystem; Calcium signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (q) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystem;
MIM	162321

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What is the role of the Human TACR2 Stable Cell Line-U2OS in studying the mechanism of neurotransmitter release?

A: The Human TACR2 Stable Cell Line-U2OS, established by stably expressing the human synaptic toxin receptor 2 (TACR2) in U2OS cells, plays a significant role in elucidating how neurotransmitters are released into the synaptic cleft through the TACR2 receptor. Researchers can simulate and observe the function of TACR2 in neural regulation using this cell line, which is crucial for understanding the pathological mechanisms of neurological diseases such as Parkinson's disease.

How is the Human TACR2 Stable Cell Line-U2OS used in drug screening to assess the specificity of drugs for the TACR2 receptor?

A: During drug screening, the Human TACR2 Stable Cell Line-U2OS can be used to evaluate the specificity of potential drugs for the TACR2 receptor. By measuring the binding affinity and functional effects of drugs on the TACR2 receptor, scientists can determine whether the drugs are selective, which is essential for developing therapeutic drugs targeting specific neurological diseases.

How is the Human TACR2 Stable Cell Line-U2OS applied in studying the role of TACR2 receptors in neurodegenerative diseases?

A: The Human TACR2 Stable Cell Line-U2OS can be used to study the role of TACR2 receptors in neurodegenerative diseases, such as Parkinson's and Alzheimer's disease. This cell line helps scientists understand the potential pathological role of TACR2 receptors in these diseases and develop potential therapeutic strategies targeting TACR2.

How is the Human TACR2 Stable Cell Line-U2OS applied in studying the function of TACR2 receptors in neural transmission?

A: The Human TACR2 Stable Cell Line-U2OS provides a platform for studying the function of TACR2 receptors in neural transmission, including their roles at the presynaptic and postsynaptic sites. This cell line helps scientists uncover the specific mechanisms of action of TACR2 receptors in neural signal transmission, which is crucial for understanding the complex functions of the nervous system.

How is the Human TACR2 Stable Cell Line-U2OS applied in studying the role of TACR2 receptors in pain perception?

A: The Human TACR2 Stable Cell Line-U2OS can be used to study the role of TACR2 receptors in pain perception, particularly in the sensitivity of nerve endings. This cell line helps scientists understand how TACR2 receptors modulate the transmission of pain signals, which is significant for developing new pain management strategies.

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