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Human SSTR3 Validated Stable Cell Line-CHO

See other products for SSTR3
Cat.No.
CSC-RG1216
Background
Somatostatin is a 14 or 28 amino acid regulatory peptide that inhibits hormone secretion from the pituitary, pancreas, and other endocrine sites. A family of 6 GPCRs, SST1, SST2A, SST2B, SST3, SST4 and SST5 , mediate the biological activity of somatostatins. The somatostatin receptors couple to Gi to inhibit cAMP production, and also increase MAP kinase signalling. Several tumors have been shown to overexpress somatostatin receptors, and binding of somatostatin to these tumor cells stimulates or inhibits proliferation, depending on the receptor subtypes expressed. However, SST3 appears to promote apoptosis, and expression of SST3 was found to be lower in gastric cancer cells than in normal gastric mucosa, in proportion to susceptibility to apoptosis induced by somatostatin analogs. In addition, SST3 is expressed in smooth muscle cells and mediates gastrointestinal contractions.
Growth Properties
Adherent
Morphology
Epithelial-like
Host Cell
CHO-K1
Ship
Dry ice
Gene Information
Official Symbol
SSTR3
Synonyms
SSTR3; somatostatin receptor 3; somatostatin receptor type 3; SS3R; SS3-R; SS-3-R; SSR-28;
Gene ID
MIM
UniProt ID
P32745
Chromosome Location
22q13.1
Pathway
Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (i) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; GPCRs, Class A Rhodopsin-like, organism-specific biosystem; Neuroactive ligand-receptor interaction, organism-specific biosystem; Neuroactive ligand-receptor interaction, conserved biosystem;
Function
G-protein coupled receptor activity; receptor activity; signal transducer activity; somatostatin receptor activity;
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>1x 10^9 vp/ml
1 x 0.2 ml
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45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-626-9181
Fax: 1-631-614-7828
Email: info@creative-biogene.com

Europe
Tel: 44-207-097-1828

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