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Cat.No. : CSC-RG1689 Host Cell: CHO-K1
| Cat. No. | CSC-RG1689 |
| Background | Neuromedin U (NMU) receptors are a group of Gq/11-protein-coupled receptors that are currently divided intotwo subtypes; NMU1 and NMU2. The two subtypes have distinct tissue distributions; NMU1 is expressed in theperiphery (especially in the gastrointestinal tract), whilst NMU2 is expressed in the central nervous system(especially in the substantia nigra, medulla oblongata and pontine reticular formation). NMU receptorsmediate diverse biological effects including contraction of the uterus, peripheral vasoconstriction causinghypertension and activation of the HPA axis resulting in decreased food intake via the CRH system. |
| Gene | NMUR1 |
| Gene Species | Homo sapiens (Human) |
| Host Cell | CHO-K1 |
| Host Cell Species | Cricetulus griseus (Chinese hamster) |
| Stability | Validated for at least 10 passages |
| Application | 1. Gene expression studies 2. Signaling pathway research 3. Drug screening and toxicology 4. Research on the mechanisms of GPCR-related diseases |
| Quality Control | Negative for bacteria, yeast, fungi and mycoplasma. |
| Shipping | Dry Ice |
| Storage | Liquid nitrogen |
| Source | CHO-K1 |
| Subgroup | Human |
| Revival | Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media. |
| Mycoplasma | Negative |
| Format | One frozen vial containing millions of cells |
| Storage | Liquid nitrogen |
| Safety Considerations |
The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach. |
| Ship | Dry ice |
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