Human MRGPRX1 Stable Cell Line-CHO-K1

Name: Human MRGPRX1 Stable Cell Line-CHO-K1
SKU: CSC-RG0893
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-RG0893

Host Cell : CHO-K1 Size : >1x10⁶ frozen cells/vial

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Cell Line Information

Cell Culture Information

Safety and Packaging

Gene Information

Cat. No.	CSC-RG0893
Background	This receptor belongs to a group of 4 sensory neuron-specific G-protein coupled receptors that are expressed solely in small diameter primary sensory neurons. MRGX1 (MAS-related GPR-X1), also known as SNSR4 (sensory neuron-specific G-protein-coupled receptor 4), is potently activated by BAM22 which evokes a large rise in intracellular calcium. Because of their very selective expression pattern in sensory neurons and because these sensory neurons transmit pain, these receptors are of interest as therapeutic targets for the development of pain medications.
Target Gene	MRGPRX1
Gene Species	Homo sapiens (Human)
Abbr	CHO-HuMRGPRX1
Alias	MRGPRX1, MRGX1, GPCR, SNSR4
Host Cell	CHO-K1
Host Cell Species	Cricetulus griseus (Chinese hamster)
Applications	1. Gene expression studies 2. Signaling pathway research 3. Drug screening and toxicology 4. Research on the mechanisms of GPCR-related diseases
Size	>1x10⁶ frozen cells/vial
Stability	Validated for at least 10 passages
Quality Control	Negative for bacteria, yeast, fungi and mycoplasma.
Storage	Liquid nitrogen
Shipping	Dry ice

Revival	Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media.
Growth Properties	Adherent
Morphology	Epithelial-like

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

Gene Name	MRGPRX1 MAS-related GPR, member X1 [ Homo sapiens ]
Gene Symbol	MRGPRX1
Synonyms	GPCR; MRGX1; SNSR4
Gene ID	259249
Uni Prot ID	Q96LB2
m RNA Refseq	NM_147199.3
Protein Refseq	NP_671732.3
Chromosome Location	11p15.1; 11
Function	G-protein coupled receptor activity;
MIM	607227

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