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Human MCHR2 Validated Stable Cell Line-1321N1

Cat.No.
CSC-RG1174
Abbr
1321N1-HuMCHR2 Validated
Alias
MCHR2,GPR145,GPRv17,MCH-2R,MCH-R2,MCHR-2
Growth Properties
Adherent
Host Cell
1321N1
Morphology
Glial
Shipping
Dry ice
Background
Melanin-concentrating hormone (MCH) is a cyclic, 19 amino acid peptide produced in the lateral hypothalamus and other regions of the mammalian brain. When administered intracerebrally or overexpressed transgenically in rodents, MCH stimulates food intake and weight gain. Two G protein-coupled receptors for MCH, MCHR1 and MCHR2, have been identified in humans, although rodents appear only to have MCHR1. Both MCHR1 and MCHR2 are expressed primarily in brain. MCHR1 has been demonstrated by genetic and pharmacological methods in rodent models to mediate obesity caused by a high fat diet or leptin deficiency. However, MCHR2 might play a similar role in the species that express it.

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