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Human KCNQ3/KCNQ5 Stable Cell Line-HEK293

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Cat.No.
CSC-RI0147
Background
The human KCNQ3 and KCNQ5 genes encode the pore-forming subunits of Kv7.3 and Kv7.5, respectively. These subunits form heteromeric voltage-gated potassium channels that underlie M-current that regulates repetitive activity in neurons. Mutations in KCNQ3 that reduce M-current are responsible for some forms of benign familial neonatal seizure. Kv7.3/Kv7.5 channels expressed in neurons are therapeutic targets in seizure and cognitive impairment.
Growth Properties
Adherent
Morphology
Epithelial
Host Cell
HEK293
Ship
Dry ice
Gene Information
Official Symbol
KCNQ5
Synonyms
KCNQ5; potassium voltage-gated channel, KQT-like subfamily, member 5; potassium voltage-gated channel subfamily KQT member 5; Kv7.5; KQT-like 5; potassium channel protein; potassium channel subunit alpha KvLQT5; voltage-gated potassium channel subunit Kv7.5;
Gene ID
MIM
UniProt ID
Q9NR82
Chromosome Location
6q14
Pathway
Cholinergic synapse, organism-specific biosystem; Neuronal System, organism-specific biosystem; Potassium Channels, organism-specific biosystem; Voltage gated Potassium channels, organism-specific biosystem;
Function
inward rectifier potassium channel activity; voltage-gated ion channel activity;

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