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Human KCND3/KCNIP1 Stable Cell Line-CHO

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Cat.No.
CSC-RI0041
Background
Rapidlly inactivating voltage sensitive potassium channels are found both in neurons (A-current) and cardiac myocytes (Ito) where they are responsible of the "notch’ in phase 1 of the cardiac action potential. The channels underlying Ito in humans are principally Kv4.3 and the regional differences in expression are thought to be governed by levels of the accessory protein KChIP2. Due to their critical role in controlling the trajectory of the action potential to differing degrees in various regions of the heart, blockade of this channel could lead to increased arrhythmic risk. In cortical, hippocampal, and striatal interneurons, KChIP1 is frequently co localized with Kv4.3. This complex of human Kv4.3 and KChIP1 represents a physiologically relevant cell line.
Growth Properties
Adherent
Morphology
Epithelial-like
Host Cell
CHO-K1
Ship
Dry ice
Gene Information
Official Symbol
KCNIP1
Synonyms
KCNIP1; Kv channel interacting protein 1; Kv channel-interacting protein 1; KCHIP1; vesicle APC-binding protein; potassium channel interacting protein 1; potassium channel-interacting protein 1; A-type potassium channel modulatory protein 1; VABP; MGC95;
Gene ID
MIM
UniProt ID
Q9NZI2
Chromosome Location
5q35
Function
calcium ion binding; ion channel activity; potassium channel regulator activity; protein N-terminus binding; protein binding; protein heterodimerization activity; voltage-gated ion channel activity;
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45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-626-9181
Fax: 1-631-614-7828
Email: info@creative-biogene.com

Europe
Tel: 44-207-097-1828

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