Human KCND3/KCNIP1 Stable Cell Line-CHO-K1

Name: Human KCND3/KCNIP1 Stable Cell Line-CHO-K1
SKU: CSC-RI0041
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-RI0041

Host Cell : CHO-K1 Size : >1x10⁶ frozen cells/vial

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Cell Line Information

Cell Culture Information

Safety and Packaging

Cat. No.	CSC-RI0041
Description	This cell line is engineered to overexpress human KCND3/KCNIP1.
Target Gene	KCND3/KCNIP1
Gene Species	Homo sapiens (Human)
Abbr	CHO-HuKCND3/KCNIP1
Alias	KCNIP1, VABP, MGC95
Host Cell	CHO-K1
Host Cell Species	Cricetulus griseus (Chinese hamster)
Applications	1. Gene expression studies 2. Signaling pathway research 3. Drug screening and toxicology 4. Channelopathies research
Size	>1x10⁶ frozen cells/vial
Stability	Validated for at least 10 passages
Quality Control	Negative for bacteria, yeast, fungi and mycoplasma.
Storage	Liquid nitrogen
Shipping	Dry ice

Revival	Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media.
Growth Properties	Adherent
Morphology	Epithelial-like

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

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Rapidlly inactivating voltage sensitive potassium channels are found both in neurons (A-current) and cardiac myocytes (Ito) where they are responsible of the "notch' in phase 1 of the cardiac action potential. The channels underlying Ito in humans are principally Kv4.3 and the regional differences in expression are thought to be governed by levels of the accessory protein KChIP2. Due to their critical role in controlling the trajectory of the action potential to differing degrees in various regions of the heart, blockade of this channel could lead to increased arrhythmic risk. In cortical, hippocampal, and striatal interneurons, KChIP1 is frequently co localized with Kv4.3. This complex of human Kv4.3 and KChIP1 represents a physiologically relevant cell line.

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