Human KCNC3 Stable Cell Line-CHO-K1

Name: Human KCNC3 Stable Cell Line-CHO-K1
SKU: CSC-RI0039
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-RI0039

Host Cell : CHO-K1 Size : >1x10⁶ frozen cells/vial

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Cell Line Information

Cell Culture Information

Safety and Packaging

Gene Information

Cat. No.	CSC-RI0039
Description	This cell line is engineered to overexpress human KCNC3.
Background	Kv3.3 are voltage-gated, fast inactivating Shaw channels which play an important role in regulating neuronal output by modulating the delay and frequency of high frequency neuronal firing. They are highly expressed in areas of the brain involved with motor control such as the cerebellum. They have also been shown be expressed at the mammalian neuromuscular junction where they are thought to regulate transmitter release.
Target Gene	KCNC3
Gene Species	Homo sapiens (Human)
Abbr	CHO-HuKCNC3
Alias	KCNC3, Kv3.3, KV3.3, SCA13
Host Cell	CHO-K1
Host Cell Species	Cricetulus griseus (Chinese hamster)
Applications	1. Gene expression studies 2. Signaling pathway research 3. Drug screening and toxicology 4. Channelopathies research
Size	>1x10⁶ frozen cells/vial
Stability	Validated for at least 10 passages
Quality Control	Negative for bacteria, yeast, fungi and mycoplasma.
Storage	Liquid nitrogen
Shipping	Dry ice

Revival	Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media.
Growth Properties	Adherent
Morphology	Epithelial-like

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

Gene Name	KCNC3 potassium voltage-gated channel, Shaw-related subfamily, member 3 [ Homo sapiens ]
Gene Symbol	KCNC3
Synonyms	KV3.3; SCA13; KSHIIID
Gene Description	potassium voltage-gated channel, Shaw-related subfamily, member 3
Gene ID	3748
Uni Prot ID	Q14003
m RNA Refseq	NM_004977.2
Protein Refseq	NP_004968.2
Chromosome Location	19q13.33
Function	voltage-gated potassium channel activity;
Pathway	Neuronal System, organism-specific biosystem; Potassium Channels, organism-specific biosystem; Voltage gated Potassium channels, organism-specific biosystem;
MIM	176264

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