Human HTR6 Stable Cell Line-CHO-K1

Name: Human HTR6 Stable Cell Line-CHO-K1
SKU: CSC-RG0774
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-RG0774

Host Cell : CHO-K1 Size : >1x10⁶ frozen cells/vial

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Cell Line Information

Cell Culture Information

Safety and Packaging

Gene Information

Cat. No.	CSC-RG0774
Background	Serotonin (5-hydroxytryptamine, 5-HT) exerts its many physiological effects through 13 distinct receptor subtypes in humans. These subtypes fall into seven structurally-defined classes (5HT1 to 5HT7). 5-HT6 receptor is expressed in several human brain regions, most prominently in the caudate nucleus. It is positively coupled to adenylcyclase and has pharmacological properties with high affinity for several therapeutically important antidepressant and antipsychotic drugs, in particular the atypical antipsychotic clozapine and related compounds.
Target Gene	HTR6
Gene Species	Homo sapiens (Human)
Abbr	CHO-HuHTR6
Alias	HTR6, 5 HT6, 5 HT6R, 5-HT-6, 5-HT6, 5-HT6R
Host Cell	CHO-K1
Host Cell Species	Cricetulus griseus (Chinese hamster)
Applications	1. Gene expression studies 2. Signaling pathway research 3. Drug screening and toxicology 4. Research on the mechanisms of GPCR-related diseases
Size	>1x10⁶ frozen cells/vial
Stability	Validated for at least 10 passages
Quality Control	Negative for bacteria, yeast, fungi and mycoplasma.
Storage	Liquid nitrogen
Shipping	Dry ice

Revival	Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media.
Growth Properties	Adherent
Morphology	Epithelial-like

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

Gene Name	HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled [ Homo sapiens ]
Gene Symbol	HTR6
Synonyms	5-HT6; 5-HT6R
Gene Description	5-hydroxytryptamine (serotonin) receptor 6
Gene ID	3362
Uni Prot ID	P50406
m RNA Refseq	NM_000871.1
Protein Refseq	NP_000862.1
Chromosome Location	1p36-p35
Function	histamine receptor activity; protein binding;
Pathway	Amine ligand-binding receptors, organism-specific biosystem; Calcium signaling pathway, organism-specific biosystem; Calcium signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (s) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem;
MIM	601109

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