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Human HTR6 Stable Cell Line-CHO

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Cat.No.
CSC-RG0774
Background
Serotonin (5-hydroxytryptamine, 5-HT) exerts its many physiological effects through 13 distinct receptor subtypes in humans. These subtypes fall into seven structurally-defined classes (5HT1 to 5HT7). 5-HT6 receptor is expressed in several human brain regions, most prominently in the caudate nucleus. It is positively coupled to adenylcyclase and has pharmacological properties with high affinity for several therapeutically important antidepressant and antipsychotic drugs, in particular the atypical antipsychotic clozapine and related compounds.
Growth Properties
Adherent
Morphology
Epithelial-like
Host Cell
CHO-K1
Stability
12 passages of continuous culture (6 weeks) at 2 passages/week
Ship
Dry ice
Gene Information
Official Symbol
HTR6
Synonyms
HTR6; 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled; 5 hydroxytryptamine (serotonin) receptor 6; 5-hydroxytryptamine receptor 6; 5 HT6; 5 HT6R; 5-HT-6; serotonin receptor 6; 5-HT6; 5-HT6R;
Gene ID
MIM
UniProt ID
P50406
Chromosome Location
1p36-p35
Pathway
Amine ligand-binding receptors, organism-specific biosystem; Calcium signaling pathway, organism-specific biosystem; Calcium signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (s) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem;
Function
G-protein coupled receptor activity; histamine receptor activity; protein binding; receptor activity; signal transducer activity;

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