Human HTR2A Stable Cell Line-U2OS

Name: Human HTR2A Stable Cell Line-U2OS
SKU: CSC-RG0022
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-RG0022

Host Cell : U2OS Size : >1x10⁶ frozen cells/vial

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Cell Line Information

Cell Culture Information

Safety and Packaging

Gene Information

Cat. No.	CSC-RG0022
Background	The serotonin receptors, also known as 5-hydroxytryptamine receptors or 5-HT receptors are a group of G protein-coupled receptors (GPCRs) found in the central and peripheral nervous systems. They mediate both excitatory and inhibitory neurotransmission. The neurotransmitter serotonin acts as their natural ligand. The 5-hydroxytryptamine receptor 2A (5-HT2A) has been involved in diverse psychiatric disorders like schizophrenia, mood disorders, anxiety disorders, obsessive-compulsive disorder, eating disorders, and Alzheimer"s disease.
Target Gene	HTR2A
Gene Species	Homo sapiens (Human)
Abbr	U2OS-HuHTR2A
Alias	HTR2A, HTR2, 5 HT2A, 5-HT-2A, HTR2, 5-HT2A
Host Cell	U2OS
Host Cell Species	Homo sapiens (Human)
Applications	1. Gene expression studies 2. Signaling pathway research 3. Drug screening and toxicology 4. Research on the mechanisms of GPCR-related diseases
Size	>1x10⁶ frozen cells/vial
Stability	Validated for at least 10 passages
Quality Control	Negative for bacteria, yeast, fungi and mycoplasma.
Storage	Liquid nitrogen
Shipping	Dry ice

Revival	Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media.
Growth Properties	Adherent

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

Gene Name	HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled [ Homo sapiens ]
Gene Symbol	HTR2A
Synonyms	HTR2A; 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled; 5 hydroxytryptamine (serotonin) receptor 2A , HTR2; 5-hydroxytryptamine receptor 2A; 5 HT2A; 5-HT-2A; 5-HT2 receptor; serotonin 5-HT-2A receptor; HTR2; 5-HT2A;
GeneID	3356
Uni ProtID	P28223
mRNA Refseq	BC069356
Chromosome Location	13q14-q21
Function	1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding; G-protein coupled receptor activity; drug binding; phosphatidylinositol phospholipase C activity; receptor activity; serotonin binding; serotonin receptor activity; signal transducer activity;
Pathway	Amine ligand-binding receptors, organism-specific biosystem; Calcium signaling pathway, organism-specific biosystem; Calcium signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (q) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem;
MIM	182135

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Customer Q&As

What is the application of the Human HTR2A Stable Cell Line-U2OS in studying the role of the serotonin receptor 2A (5-HT2A) in mental disorders?

A: The Human HTR2A Stable Cell Line-U2OS, which stably expresses the human serotonin receptor 2A (HTR2A) in U2OS cells, simulates the function of this receptor. This cell line is crucial for studying the role of HTR2A in mental disorders such as schizophrenia and depression. It aids scientists in understanding how HTR2A influences neural transmission and brain function, which is significant for developing new treatment strategies.

How does the Human HTR2A Stable Cell Line-U2OS assist in drug screening to identify potential antipsychotic drugs?

A: Drug screening on the Human HTR2A Stable Cell Line-U2OS allows researchers to evaluate the affinity and effects of potential drugs on the HTR2A receptor. This cell line provides a platform for identifying and optimizing compounds that can affect HTR2A activity, which is significant for developing drugs to treat mental disorders.

How is the Human HTR2A Stable Cell Line-U2OS applied in studying the role of HTR2A receptors in neurodegenerative diseases?

A: The Human HTR2A Stable Cell Line-U2OS can be used to study the role of HTR2A receptors in neurodegenerative diseases, such as Parkinson's disease. This cell line helps scientists understand the expression and functional changes of HTR2A receptors in these diseases and how they affect the survival and death of neural cells.

How is the Human HTR2A Stable Cell Line-U2OS applied in studying the role of HTR2A receptors in cognitive function?

A: The Human HTR2A Stable Cell Line-U2OS can be used to study the role of HTR2A receptors in cognitive function, including memory and attention processes. This cell line helps scientists understand how HTR2A receptors influence cognitive processes in the brain, which has potential value for developing drugs to improve cognitive function.

How is the Human HTR2A Stable Cell Line-U2OS applied in studying the role of HTR2A receptors in pain perception?

A: The Human HTR2A Stable Cell Line-U2OS can be used to study the role of HTR2A receptors in pain perception, particularly in the sensitivity of nerve endings. This cell line helps scientists understand how HTR2A receptors modulate the transmission of pain signals, which is significant for developing new pain management strategies.

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