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Cat.No. : CSC-RG0022 Host Cell: U2OS
| Cat. No. | CSC-RG0022 |
| Background | The serotonin receptors, also known as 5-hydroxytryptamine receptors or 5-HT receptors are a group of G protein-coupled receptors (GPCRs) found in the central and peripheral nervous systems. They mediate both excitatory and inhibitory neurotransmission. The neurotransmitter serotonin acts as their natural ligand. The 5-hydroxytryptamine receptor 2A (5-HT2A) has been involved in diverse psychiatric disorders like schizophrenia, mood disorders, anxiety disorders, obsessive-compulsive disorder, eating disorders, and Alzheimer"s disease. |
| Gene | HTR2A |
| Gene Species | Homo sapiens (Human) |
| Alias | HTR2A, HTR2, 5 HT2A, 5-HT-2A, HTR2, 5-HT2A |
| Host Cell | U2OS |
| Species | Homo sapiens (Human) |
| Morphology | Epithelial |
| Stability | Validated for at least 10 passages |
| Application | 1. Gene expression studies 2. Signaling pathway research 3. Drug screening and toxicology 4. Research on the mechanisms of GPCR-related diseases |
| Quality Control | Negative for bacteria, yeast, fungi and mycoplasma. |
| Shipping | Dry ice |
| Storage | Liquid nitrogen |
| Revival | Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media. |
| Growth Properties | Adherent |
| Mycoplasma | Negative |
| Format | One frozen vial containing millions of cells |
| Storage | Liquid nitrogen |
| Safety Considerations |
The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach. |
| Ship | Dry ice |
A: The Human HTR2A Stable Cell Line-U2OS, which stably expresses the human serotonin receptor 2A (HTR2A) in U2OS cells, simulates the function of this receptor. This cell line is crucial for studying the role of HTR2A in mental disorders such as schizophrenia and depression. It aids scientists in understanding how HTR2A influences neural transmission and brain function, which is significant for developing new treatment strategies.
A: Drug screening on the Human HTR2A Stable Cell Line-U2OS allows researchers to evaluate the affinity and effects of potential drugs on the HTR2A receptor. This cell line provides a platform for identifying and optimizing compounds that can affect HTR2A activity, which is significant for developing drugs to treat mental disorders.
A: The Human HTR2A Stable Cell Line-U2OS can be used to study the role of HTR2A receptors in neurodegenerative diseases, such as Parkinson's disease. This cell line helps scientists understand the expression and functional changes of HTR2A receptors in these diseases and how they affect the survival and death of neural cells.
A: The Human HTR2A Stable Cell Line-U2OS can be used to study the role of HTR2A receptors in cognitive function, including memory and attention processes. This cell line helps scientists understand how HTR2A receptors influence cognitive processes in the brain, which has potential value for developing drugs to improve cognitive function.
A: The Human HTR2A Stable Cell Line-U2OS can be used to study the role of HTR2A receptors in pain perception, particularly in the sensitivity of nerve endings. This cell line helps scientists understand how HTR2A receptors modulate the transmission of pain signals, which is significant for developing new pain management strategies.
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