Serotonin (5-hydroxytryptamine, 5-HT) exerts its many physiological effects through 13 distinct receptor subtypes in humans. These subtypes fall into seven structurally-defined classes (5-HT1 to 5-HT7). Among them, 5-HT1a receptors are expressed mainly in the CNS where they induce neuronal inhibition and control behavior, such as sleep, food intake, thermoregulation, aggression, and anxiety. This receptor has been used as a target for developing drugs to treat anxiety and depression.
12 passages of continuous culture (6 weeks at 2 passages/week)