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Human GRM7 Validated Stable Cell Line

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Cat.No.
CSC-RG1165
Background
L-glutamate is the major excitatory neurotransmitter in the central nervous system, and it activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into three groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5, and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3, while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene.
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Dry ice
Gene Information
Official Symbol
GRM7
Synonyms
GRM7; glutamate receptor, metabotropic 7; metabotropic glutamate receptor 7; GLUR7; GPRC1G; mGlu7; MGLUR7; MGLU7; FLJ40498;
Gene ID
MIM
UniProt ID
Q14831
Chromosome Location
3p26-p25
Pathway
Class C/3 (Metabotropic glutamate/pheromone receptors), organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; GPCRs, Class C Metabotropic glutamate, pheromone, organism-specific biosystem; Glutamatergic synapse, organism-specific biosystem; Glutamatergic synapse, conserved biosystem; Neuroactive ligand-receptor interaction, organism-specific biosystem; Neuroactive ligand-receptor interaction, conserved biosystem;
Function
G-protein coupled receptor activity; PDZ domain binding; adenylate cyclase inhibitor activity; calcium channel regulator activity; calcium ion binding; glutamate binding; glutamate receptor activity; group III metabotropic glutamate receptor activity; receptor activity; serine binding; signal transducer activity; voltage-gated calcium channel activity;

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