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Human GRIN1/GRIN2B Stable Cell Line-HEK293

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Cat.No.
CSC-RI0175
Background
The human GRIN1/GRIN2B genes encode the cationic-selective, n-methyl-d-aspartic acid receptor-channel expressed in the CNS. NMDA receptors are therapeutic targets in treatment of neurological disorders including seizure, pain, and Alzheimer"s disease.
Growth Properties
Adherent
Morphology
Epithelial
Host Cell
HEK293
Ship
Dry ice
Gene Information
Official Symbol
GRIN2B
Synonyms
GRIN2B; glutamate receptor, ionotropic, N-methyl D-aspartate 2B; NMDAR2B; glutamate [NMDA] receptor subunit epsilon-2; GluN2B; NR3; glutamate receptor subunit epsilon-2; N-methyl-D-aspartate receptor subunit 3; N-methyl D-aspartate receptor subtype 2B; MRD6; NR2B; hNR3; MGC142178; MGC142180;
Gene ID
MIM
UniProt ID
Q13224
Chromosome Location
12p12
Pathway
Activation of NMDA receptor upon glutamate binding and postsynaptic events, organism-specific biosystem; Alzheimers disease, organism-specific biosystem; Alzheimers disease, conserved biosystem; Amphetamine addiction, organism-specific biosystem; Amphetamine addiction, conserved biosystem; Amyotrophic lateral sclerosis (ALS), organism-specific biosystem; Amyotrophic lateral sclerosis (ALS), conserved biosystem;
Function
D2 dopamine receptor binding; N-methyl-D-aspartate selective glutamate receptor activity; beta-catenin binding; cell adhesion molecule binding; drug binding; extracellular-glutamate-gated ion channel activity; glycine binding; ion channel activity; ionotropic glutamate receptor binding; metal ion binding; neurotransmitter binding; protein binding; protein heterodimerization activity; receptor activity; receptor binding; transporter activity; zinc ion binding;

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