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Human GPBAR1 Stable Cell Line-CHO-K1

Cat.No.
CSC-RG1650
Host Cell
CHO-K1
Shipping
Dry Ice
Source
CHO-K1
Species
Human
Subgroup
Human
Background
This gene encodes a member of the G protein-coupled receptor (GPCR) superfamily. This enzyme functions as a cell surface receptor for bile acids. Treatment of cells expressing this GPCR with bile acids induces the production of intracellular cAMP, activation of a MAP kinase signaling pathway, and internalization of the receptor. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids. Alternative splicing results in multiple transcript variants encoding the same protein.
Gene Information
GPBAR1
BG37; TGR5; M-BAR; GPCR19; GPR131
G protein-coupled bile acid receptor 1
Q8TDU6
2q35
G-protein coupled receptor activity;
Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (s) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; Signal Transduction, organism-specific biosystem; Signaling by GPCR, organism-specific biosystem;

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