Cat.No. : CSC-RG1650 Host Cell: CHO-K1
| Cat. No. | CSC-RG1650 |
| Background | This gene encodes a member of the G protein-coupled receptor (GPCR) superfamily. This enzyme functions as a cell surface receptor for bile acids. Treatment of cells expressing this GPCR with bile acids induces the production of intracellular cAMP, activation of a MAP kinase signaling pathway, and internalization of the receptor. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids. Alternative splicing results in multiple transcript variants encoding the same protein. |
| Gene | GPBAR1 |
| Gene Species | Homo sapiens (Human) |
| Host Cell | CHO-K1 |
| Species | Cricetulus griseus (Chinese hamster) |
| Stability | Validated for at least 10 passages |
| Application | 1. Gene expression studies 2. Signaling pathway research 3. Drug screening and toxicology 4. Research on the mechanisms of GPCR-related diseases |
| Quality Control | Negative for bacteria, yeast, fungi and mycoplasma. |
| Shipping | Dry Ice |
| Storage | Liquid nitrogen |
| Source | CHO-K1 |
| Subgroup | Human |
| Revival | Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media. |
| Gene Name | GPBAR1 G protein-coupled bile acid receptor 1 [ Homo sapiens ] |
| Gene Symbol | GPBAR1 |
| Synonyms | BG37; TGR5; M-BAR; GPCR19; GPR131 |
| Gene Description | G protein-coupled bile acid receptor 1 |
| Gene ID | 151306 |
| UniProt ID | Q8TDU6 |
| mRNA Refseq | NM_001077191.1 |
| Protein Refseq | NP_001070659.1 |
| Chromosome Location | 2q35 |
| Function | G-protein coupled receptor activity; |
| Pathway | Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (s) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; Signal Transduction, organism-specific biosystem; Signaling by GPCR, organism-specific biosystem; |
| MIM | 610147 |
| Mycoplasma | Negative |
| Format | One frozen vial containing millions of cells |
| Storage | Liquid nitrogen |
| Safety Considerations |
The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach. |
| Ship | Dry ice |
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