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Human GPBAR1 Stable Cell Line-CHO-K1

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Cat.No.
CSC-RG1650
Background
This gene encodes a member of the G protein-coupled receptor (GPCR) superfamily. This enzyme functions as a cell surface receptor for bile acids. Treatment of cells expressing this GPCR with bile acids induces the production of intracellular cAMP, activation of a MAP kinase signaling pathway, and internalization of the receptor. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids. Alternative splicing results in multiple transcript variants encoding the same protein.
Host Cell
CHO-K1
Ship
Dry Ice
Antigen Gene Information
Official Symbol
GPBAR1
Synonyms
GPBAR1; BG37; GPCR19; GPR131; M-BAR; TGR5; G protein-coupled bile acid receptor 1; G-protein coupled bile acid receptor 1; hBG37; hGPCR19; membrane bile acid receptor; G-protein coupled receptor GPCR19; membrane-type receptor for bile acids; G-protein coupled bile acid receptor BG37
GeneID
MIM
UniProt ID
Q8TDU6
Chromosome Location
2q35
Pathway
Class A/1 (Rhodopsin-like receptors); GPCR ligand binding; Signal Transduction; Signal by GPCR; G alpha (s) signalling events; GPCR downstream signaling
Function
G-protein coupled receptor activity

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