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Human GPBAR1 Stable Cell Line-CHO-K1

Cat.No.
CSC-RG1650
Host Cell
CHO-K1
Shipping
Dry Ice
Source
CHO-K1
Species
Human
Subgroup
Human
Background
This gene encodes a member of the G protein-coupled receptor (GPCR) superfamily. This enzyme functions as a cell surface receptor for bile acids. Treatment of cells expressing this GPCR with bile acids induces the production of intracellular cAMP, activation of a MAP kinase signaling pathway, and internalization of the receptor. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids. Alternative splicing results in multiple transcript variants encoding the same protein.
Gene Information
Gene Symbol
GPBAR1
Synonyms
BG37; TGR5; M-BAR; GPCR19; GPR131
Gene Description
G protein-coupled bile acid receptor 1
Gene ID
UniProt ID
Q8TDU6
mRNA Refseq
Protein Refseq
Chromosome Location
2q35
Function
G-protein coupled receptor activity;
Pathway
Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (s) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; Signal Transduction, organism-specific biosystem; Signaling by GPCR, organism-specific biosystem;
MIM

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