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Human EDNRA Stable Cell Line-CHO

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Cat.No.
CSC-RG0838
Background
Endothelins are a family of vasoactive peptides that include ET-1, ET-2 and ET-3. To date, two subtype of endothelin receptors have been identified from mammalian cells, EDNRA (ETA) and EDNRB (ETB). The EDNRA receptors (ETA) have a much greater affinity for ET-1 over ET-3 and are expressed abundantly in vascular smooth muscles and stromal tissues. The vasoconstrictor and proliferative effects of ET-1 are primarily mediated by the EDNRA receptor. This makes EDNRA a good target for drug development in a number of cardiovascular diseases, including congestive heart failure, hypertension, stroke, kidney failure, and a variety of non-cardiovascular conditions, such as asthma, chronic obstructive pulmonary disease, pain and cancer.
Growth Properties
Adherent
Morphology
Epithelial-like
Host Cell
CHO-K1
Stability
12 passages of continuous culture (6 weeks) at 2 passages/week
Ship
Dry ice
Gene Information
Official Symbol
EDNRA
Synonyms
EDNRA; endothelin receptor type A; endothelin-1 receptor; G protein-coupled receptor; endothelin receptor subtype A; endothelin-1-specific receptor; ETA; ET-A; ETAR; ETRA; ETA-R; hET-AR;
Gene ID
MIM
UniProt ID
P25101
Chromosome Location
4
Pathway
Calcium signaling pathway, organism-specific biosystem; Calcium signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; EGFR-dependent Endothelin signaling events, organism-specific biosystem; Endothelins, organism-specific biosystem; G alpha (q) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem;
Function
G-protein coupled receptor activity; endothelin receptor activity; phosphatidylinositol phospholipase C activity; receptor activity; signal transducer activity;

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