Human CHRM5 Stable Cell Line-U2OS

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Cat.No.

CSC-RG0015

Background

Muscarinic acetylcholine receptors are G protein-coupled receptors. M1, M3, M5 receptors couple to G proteins of the Gq/11 family, which activate phospholipase C. M2 and M4 receptors couple to Gi/o-type G proteins that inhibit adenylyl cyclase activity. Muscarinic receptors control many effects of acetylcholine in the central and peripheral nervous system. The clinical implications of this receptor have not been fully explored; however, stimulation of this receptor is known to effectively decrease cAMP levels and downregulate the activity of protein kinase A (PKA).

Growth Properties

Adherent

Morphology

Epithelial

Host Cell

U2OS

Ship

Dry ice

Gene Information

Gene Name

CHRM5 cholinergic receptor, muscarinic 5 [ Homo sapiens ]

Official Symbol

CHRM5

Synonyms

CHRM5; cholinergic receptor, muscarinic 5; muscarinic acetylcholine receptor M5; acetylcholine receptor; muscarinic 5; acetylcholine receptor, muscarinic 5; HM5; MGC41838;

Gene ID

1133

MIM

118496

UniProt ID

P08912

Chromosome Location

15q26

Pathway

Amine ligand-binding receptors, organism-specific biosystem; Calcium Regulation in the Cardiac Cell, organism-specific biosystem; Calcium signaling pathway, organism-specific biosystem; Calcium signaling pathway, conserved biosystem; Cholinergic synapse, organism-specific biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (q) signalling events, organism-specific biosystem;

Function

G-protein coupled acetylcholine receptor activity; G-protein coupled receptor activity; phosphatidylinositol phospholipase C activity; receptor activity; signal transducer activity;

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Gene Symbol

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CHRM5

Human