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Cat.No. : CSC-RO0232 Host Cell: GS-C1
| Cat. No. | CSC-RO0232 |
| Description | This cell line is engineered to stably overexpress the human CD80 in GS-C1 cells. |
| Introduction | GS-C1/CD80 cell line stably expresses human CD80 molecule. The expression of CD80 in this cell line has been validated through flow cytometry. The functional validation of this cell line has been measured by cell-based anti-CTLA4 activity assay. |
| Gene | CD80 |
| Gene Species | Homo sapiens (Human) |
| Host Cell | GS-C1 |
| Host Cell Species | Homo sapiens (Human) |
| Stability | Validated for at least 10 passages |
| Application | 1. Studying the interactions between immune cells and cancer cells 2. Studying the mechanisms of resistance to immune checkpoint blockade 3. High-throughput screening 4. Drug target validation |
| Quality Control | Negative for bacteria, yeast, fungi and mycoplasma. |
| Shipping | Dry ice |
| Storage | Liquid nitrogen |
| Revival | Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media. |
| Mycoplasma | Negative |
| Format | One frozen vial containing millions of cells |
| Storage | Liquid nitrogen |
| Safety Considerations |
The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach. |
| Ship | Dry ice |
A: The Human CD80 Stable Cell Line - GS-C1 is instrumental in studying the role of CD80 (B7-1) in T cell activation and co-stimulation. CD80 is a critical co-stimulatory molecule that interacts with CD28 on T cells, enhancing their activation. This cell line allows researchers to investigate the molecular mechanisms of T cell activation and the potential therapeutic targets for autoimmune diseases and cancer immunotherapy.
A: The unique features of the Human CD80 Stable Cell Line - GS-C1 include its stable expression of CD80, which enables researchers to perform a wide range of immunological studies, such as investigating the interaction between CD80 and its receptors, its role in antigen presentation, and its involvement in regulatory T cell function.
A: The cell line can be used in high-throughput screening assays to identify compounds that modulate CD80 expression or function. This could lead to the discovery of new drugs that enhance or inhibit T cell responses, which are crucial for the development of immunotherapies for various diseases, including cancer and autoimmune disorders.
A: The cell line can be used to investigate how CD80 contributes to immune tolerance by studying its interactions with regulatory T cells and other immune cells. This can help elucidate the mechanisms behind autoimmune diseases where CD80-mediated co-stimulation may be dysregulated.
A: While the use of cell lines like GS-C1 does not raise the same ethical concerns as primary human tissue, researchers must still adhere to ethical guidelines for cell culture, including obtaining informed consent for the original cell source and ensuring the proper disposal of cell lines.
A: The cell line can serve as a platform for introducing specific genetic variations into the CD80 gene, allowing researchers to assess how these variations affect CD80 function and the resulting immune responses. This can provide insights into the genetic basis of individual differences in immune responses.
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