Human CCKAR Stable Cell Line-CHO-K1

Name: Human CCKAR Stable Cell Line-CHO-K1
SKU: CSC-RG0819
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-RG0819

Host Cell : CHO-K1 Size : >1x10⁶ frozen cells/vial

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Cell Line Information

Cell Culture Information

Safety and Packaging

Gene Information

Cat. No.	CSC-RG0819
Background	Cholecystokinin (CCK) is a neuropeptide which is widely distributed in the mammalian central nervous system. Two CCK receptors have been identified to mediate the effects of CCK/gastrin family: CCKA (or CCK-1) receptor and CCKB (or CCK-2 or gastrin receptor). The CCKA receptor has a more limited distribution with highest densities in the hypothalamic nuclei, areas of the hippocampus, the septum, dorsal motor vagal nucleus and interpeduncular nucleus of the brain stem. It also occurs in numerous gastro-intestinal tissues. CCKA receptors affect satiety, pancreatitis, gut motility and have growth-promoting effects on some tumors.
Target Gene	CCKAR
Gene Species	Homo sapiens (Human)
Abbr	CHO-HuCCKAR
Alias	CCKAR, CCK-AR, CCK-A, CCKRA, CCK1-R
Host Cell	CHO-K1
Host Cell Species	Cricetulus griseus (Chinese hamster)
Applications	1. Gene expression studies 2. Signaling pathway research 3. Drug screening and toxicology 4. Research on the mechanisms of GPCR-related diseases
Size	>1x10⁶ frozen cells/vial
Stability	Validated for at least 10 passages
Quality Control	Negative for bacteria, yeast, fungi and mycoplasma.
Storage	Liquid nitrogen
Shipping	Dry ice

Revival	Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media.
Growth Properties	Adherent
Morphology	Epithelial-like

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

Gene Name	CCKAR cholecystokinin A receptor [ Homo sapiens ]
Gene Symbol	CCKAR
Synonyms	CCK-A; CCKRA; CCK1-R
Gene Description	cholecystokinin A receptor
Gene ID	886
Uni Prot ID	P32238
m RNA Refseq	NM_000730.2
Protein Refseq	NP_000721.1
Chromosome Location	4p15.1-p15.2
Function	cholecystokinin receptor activity;
Pathway	Calcium signaling pathway, organism-specific biosystem; Calcium signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (q) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; GPCRs, Class A Rhodopsin-like, organism-specific biosystem;
MIM	118444

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