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Cat.No. : CSC-RG0045 Host Cell: CHO
| Cat. No. | CSC-RG0045 |
| Background | This gene encodes a G-protein coupled receptor that binds non-sulfated members of the cholecystokinin (CCK) family of peptide hormones. This receptor is a major physiologic mediator of pancreatic enzyme secretion and smooth muscle contraction of the gallbladder and stomach. In the central and peripheral nervous system this receptor regulates satiety and the release of beta-endorphin and dopamine. |
| Gene | CCKAR |
| Gene Species | Homo sapiens (Human) |
| Alias | CCKAR, CCK-AR, CCK-A, CCKRA, CCK1-R |
| Host Cell | CHO |
| Species | Cricetulus griseus (Chinese hamster) |
| Morphology | Epithelial-like |
| Stability | Validated for at least 10 passages |
| Application | 1. Gene expression studies 2. Signaling pathway research 3. Drug screening and toxicology 4. Research on the mechanisms of GPCR-related diseases |
| Quality Control | Negative for bacteria, yeast, fungi and mycoplasma. |
| Shipping | Dry ice |
| Storage | Liquid nitrogen |
| Revival | Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media. |
| Growth Properties | Adherent |
| Mycoplasma | Negative |
| Format | One frozen vial containing millions of cells |
| Storage | Liquid nitrogen |
| Safety Considerations |
The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach. |
| Ship | Dry ice |
A: The Human CCKAR-SNAP Stable Cell Line-CHO offers several advantages for GPCR (G-protein coupled receptor) signaling studies. It allows for the study of CCKAR (Cholecystokinin A receptor) in a controlled environment, which is crucial for understanding its role in various physiological processes. The SNAP tag enables the cell line to be used for biochemistry and imaging applications, such as protein trafficking and dynamic localization studies. Additionally, the CHO (Chinese Hamster Ovary) host provides a robust and well-characterized system for protein expression and modification, which is essential for high-quality data collection.
A: This cell line is instrumental in drug discovery as it provides a platform for high-throughput screening of potential CCKAR modulators. By studying the receptor's activity and response to various compounds, researchers can identify potential drug candidates that modulate CCKAR, which could be useful in treating conditions related to its dysregulation.
A: The SNAP tag allows for the visualization of the CCKAR receptor's movement within the cell. By attaching fluorescent probes to the SNAP tag, researchers can track the receptor's trafficking pathways and internalization dynamics in real-time, providing insights into the cellular processes associated with GPCR function.
A: By studying the CCKAR receptor in a controlled environment, researchers can investigate its involvement in various diseases, such as obesity, diabetes, and neurological disorders. This cell line provides a platform for studying the receptor's function in the context of disease-related pathways and identifying potential therapeutic targets.
A: While this cell line provides a valuable model, it may not fully replicate the complex environment of the human body. Factors such as cell-cell interactions, tissue-specific expression, and the influence of other signaling pathways may not be accurately represented. Additionally, the CHO host system may introduce species-specific differences that could affect the interpretation of results.
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