Human AGTR1 Stable Cell Line-CHO-K1

Name: Human AGTR1 Stable Cell Line-CHO-K1
SKU: CSC-RG0802
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-RG0802

Host Cell : CHO-K1 Size : >1x10⁶ frozen cells/vial

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Cell Line Information

Cell Culture Information

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Gene Information

Cat. No.	CSC-RG0802
Background	Two receptors for angiotensin II have been identified, AT1 and AT2 receptors. AT1 receptor antagonists have been shown to lower arterial blood pressure, reduce cardiac load, inhibit sympathetic activity and prevent cardiovascular hypertrophy.
Target Gene	AGTR1
Gene Species	Homo sapiens (Human)
Abbr	CHO-HuAGTR1
Alias	AGTR1, AG2S, AGTR1A, AT1, AT1B, AT2R1, AT2R1A, AT2R1B, HAT1R, AT1AR, AT1BR, AT1R, AGTR1B
Host Cell	CHO-K1
Host Cell Species	Cricetulus griseus (Chinese hamster)
Applications	1. Gene expression studies 2. Signaling pathway research 3. Drug screening and toxicology 4. Research on the mechanisms of GPCR-related diseases
Size	>1x10⁶ frozen cells/vial
Stability	Validated for at least 10 passages
Quality Control	Negative for bacteria, yeast, fungi and mycoplasma.
Storage	Liquid nitrogen
Shipping	Dry ice

Revival	Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media.
Growth Properties	Adherent
Morphology	Epithelial-like

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

Gene Name	AGTR1 angiotensin II receptor, type 1 [ Homo sapiens ]
Gene Symbol	AGTR1
Synonyms	AT1; AG2S; AT1B; AT1R; AT1AR; AT1BR; AT2R1; HAT1R; AGTR1A; AGTR1B; AT2R1A; AT2R1B
Gene Description	angiotensin II receptor, type 1
Gene ID	185
Uni Prot ID	P30556
m RNA Refseq	NM_000685.4
Protein Refseq	NP_000676.1
Chromosome Location	3q24
Function	acetyltransferase activator activity; angiotensin type I receptor activity; angiotensin type I receptor activity; angiotensin type II receptor activity; bradykinin receptor binding; protein binding; protein heterodimerization activity;
Pathway	ACE Inhibitor Pathway, organism-specific biosystem; Angiopoietin receptor Tie2-mediated signaling, organism-specific biosystem; Arf6 signaling events, organism-specific biosystem; Calcium signaling pathway, organism-specific biosystem; Calcium signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (q) signalling events, organism-specific biosystem;
MIM	106165

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